rtms对抑郁障碍患者慢性皮层电位的运动阈值及θβ比值的影响.docVIP

精品论文 参考文献 rTMS对抑郁障碍患者慢性皮层电位的运动阈值及θβ比值的影响 （长春市第六医院 吉林 长春 130052） 【摘 要】目的：探讨rTMS对抑郁发作患者慢性皮层电位的运动阈值及theta;/beta;比值的影响。方法：选取抑郁发作患者60例，在常规药物治疗基础上，随机分成单纯药物治疗组（对照组）和辅助rTMS治疗组（rTMS组）;rTMS组患者采用左侧前额叶治疗（10Hz、100%MT刺激总量750/次），每日一次;治疗前与治疗2周后分别进行SAS、SDS、SCL-90、慢性皮层电位的运动阈值及theta;/beta;比值检查。结果：两组在治疗前SAS、SDS、SCL-90、慢性皮层电位的运动阈值及theta;/beta;比值检查相比无差异性（p＞0.05）。治疗后2周，rTMS组SAS、SDS、SCL-90总分下降明显，与对照组相比有差异性（p＜0.03），两组各因子分rTMS组比对照组下降明显，躯体化、强迫、敌对、精神病性、其他因素无差别性（p＞0.05），人际、抑郁、焦虑、恐怖、偏执有差别性（分别为p＜0.01，p＜0.03， p＜0.05）；rTMS组慢性皮层电位的运动阈值比对照组下降明显（p＜0.01），慢性皮层电位theta;/beta;比值略增加，但无差异性（p＞0.05）。结论：rTMS可以有效的改善抑郁发作患者的抑郁、焦虑、人际关系、恐怖、偏执临床症状，降低大脑皮层的运动阈值，对大脑功能状态没有影响。 【关键词】rTMS；抑郁障碍；慢性皮层电位 【中图分类号】R543.1 【文献标识码】A 【文章编号】1004-6194（2015）02-0187-02 【Abstract】Objective: To explore the effect of chronic cortical potentials motion threshold and theta;/beta; ratio when we used rTMS to treat the patients of depressive disorder. Methods: We selected 60 depression patients with routine drug to divide into two groups: simple drug treatment group (control group) and auxiliary rTMS treatment group (rTMS group). The patients of rTMS group would adopt left prefrontal treatment once a day (10Hz, 100%MT stimulate total 750/time), than check SAS,SDS,SCL-90,chronic cortical potentials motion threshold and theta;/beta; ratio before and after two weeks. Results: There were no significant difference (pgt;0.05) before treatment in two groups. After two weeks, the total score of SAS, SDS, SCL-90, decreased significantly and showed difference with the control group (P lt; 0.03).All of factor scores went down. There were no significant differences about somatization, compulsion, hostility, psychotic and others (pgt;0.05), but significant difference about interpersonal relationship p, depression, anxiety, phobia, paranoid (P lt; 0.01, P lt; 0.03, P lt; 0.05) between control group and rTMS group. The chronic cortical potentials motion threshold of rTMS group decreased more than control group （p＜0.01）,andtheta;/beta; ratio i