丙种球蛋白对ev71感染相关肺出血高危患儿治疗的疗效研究.docVIP

精品论文 参考文献 丙种球蛋白对EV71感染相关肺出血高危患儿治疗的疗效研究 赵真 宋春兰 成怡冰 [摘 要] 目的 探索丙种球蛋白对EV71感染相关肺出血高危患儿治疗的疗效。方法 对97例重症手足口病（神经系统损害）患儿随机分为两组，对照组给予基础治疗，观察组在基础治疗的基础上给予丙种球蛋白（IVIG）1g/kgmiddot;d，连续治疗2天；观察两组患儿发热持续时间、神经系统症状消退时间、ICU治疗时间，治疗后需有创机械通气例数、机械通气天数，肺出血例数，治疗前后T细胞亚群变化，两组患儿治疗前后IL-6、IL-10、IFN-gamma;的变化。结果 观察组与对照组相比，患儿发热持续时间、神经系统症状消退时间、ICU治疗时间、机械通气天数均有缩短，需有创机械通气及肺出血例数下降，T细胞亚群、IL-6、IL-10、IFN-gamma;的变化均明显；差异有统计学意义（Plt;0.05）。结论 对EV71感染相关肺出血高危患儿早期应用IVIG干预疗效显著。 [关键词] EV71病毒 肺出血 丙种球蛋白 DOI:10.3760/cma.j.issn.0376-2491.2016.16.29 作者单位：450003，河南省郑州市，郑州市儿童医院 通讯作者：成怡冰，Email: chengyibing002@163.com。 支持项目：常州四药临床药学科研基金（CZSYJJ14015）。 The Research about Intravenous immunoglobulin in Children with EV71 infection Having High-risk pulmonary hemorrhage Zhao Zhen,Song Chun-Lan ，Cheng Yi-Bing Abstract：Objective To explore the treatment effects of intravenous immunoglobulin in children with EV71 infection having high-risk pulmonary hemorrhage. Methods 97 cases of severe hand, foot and mouth disease (neurological damage) were randomly divided into two groups. The control group was given basic treatment, the observation group was treated with intravenous immunoglobulin (IVIG) 1g / kgmiddot;d for 2 days combined with the basis of the treatment. Changes in the two groups were observed, including persistent fever time, nervous system symptoms subsided time, treatment time in ICU, the number of invasive mechanical ventilation, duration of mechanical ventilation, pulmonary hemorrhage cases, T cell subsets, IL-6, IL-10 and IFN-gamma;. Results Persistent fever time, nervous system symptoms subsided time, treatment time in ICU, the number of invasive mechanical ventilation, duration of mechanical ventilation, pulmonary hemorrhage cases were decreased in observation group compared with control group. In addition, T cell subsets, IL-6, IL-10 and IFN -gamma; were changed significantly. The difference was statistically significant (p lt; 0.05). Conclusion There were good clinical effects in early interventi