MR评价壁虎活性成分对小鼠结肠癌移植瘤疗效的研究.docVIP

精品论文 参考文献 MR评价壁虎活性成分对小鼠结肠癌移植瘤疗效的研究 崔社娟1 王旭东2 祝令称1 赵瑶1 张仕状2（通讯作者） 　　（1潍坊医学院医学影像学系 山东潍坊 261053） 　　（2潍坊医学院附属医院影像中心 261031） 　　【摘要】目的 探讨MRI评价壁虎活性成分BH1273209对小鼠CT-26结肠癌移植瘤疗效的价值。方法 建立小鼠CT-26结肠癌移植瘤模型，一周后筛选成瘤均匀的30只荷瘤鼠随机分为A组、B组和C组，分别给予壁虎活性成分150mg/kg、5-氟尿嘧啶20mg/kg 和0.9 生理盐水 10ml/kg，每天一次。14天后行MRI检查，肿瘤行HE染色。结果 MRI：肿瘤呈不均匀长T1、长T2信号。A组肿瘤DWI信号强度(594.2plusmn;119.23)和B组肿瘤(594.4plusmn;95.54) 无明显差异(Pgt;0.05)，均较C组肿瘤(997.1plusmn;112.62)明显降低(Plt;0.05)。A组肿瘤(0.0009plusmn;0.00012) mm2/s 和B组肿瘤组织ADC值(0.00089plusmn;0.0001)无明显差异(Pgt;0.01)，均较C组肿瘤(0.0004plusmn;0.0002) mm2/s明显增高(Plt;0.01)。HE结果：A组和B组肿瘤细胞核固缩，碎裂；C组肿瘤细胞核大深染。结论 MR可以准确、实时的评价BH1273209对鼠CT-26结肠癌移植瘤的作用效果。壁虎活性单体BH1273209具有和5-氟尿嘧啶相似的抗肿瘤作用。 　　【关键词】 壁虎活性单体 磁共振成像 CT-26移植瘤 　　【中图分类号】R73-3 【文献标识码】A 【文章编号】1672-5085（2013）39-0040-02 　　The Study of MR in Evaluation of Therapeutic Effects of Gecko Active Monomer on mice CT-26 Transplant Tumors 　　CUI She Juan, WANG Xu Dong,ZHAO Yao,ZHU Ling Chen, ZHANG Shi-zhuang 　　(WeiFang Medical University, Department of Medical Imaging, Weifang 261053, China) 　　【Abstract】Objective To explore the value of MRI in evaluating of antineoplasmic activity component in Gekko swinhonis named BH1273209 for mice CT-26 transplant 　　tumors. Methods Established of mice CT-26 transplant tumors model, after a week, 30 mice with tumor uniform were choose and randomly divided into group A, group B and group C. Then were treated with intravenous injection of activity component 150 mg/kg,5-fluorouracil 20mg/kg and saline 10ml/kg for 14 days ,respectively. MR imaging (MRI) scan can be maked. Results Tumor were displayed fragmental long T1 signal and long T2 signal. The tumor DWI signal intensity of group A tumor tissue (594.2plusmn;119.23) and group B (594.4plusmn;95.54) were significantly lower than group C (997.1plusmn;112.62) (Plt;0.05) .Compared to the group C(0.0004plusmn;0.0002) mm2/s (Plt;0.01), The ADC value of group A tumor tissue (0.0009plusmn;0.00012) mm2/s and g