二甲双胍和胰岛素治疗妊娠合并糖尿病对母婴结局的影响.docVIP

精品论文 参考文献 二甲双胍和胰岛素治疗妊娠合并糖尿病对母婴结局的影响 陈刚 云南省个旧市妇幼保健院 661000 　　摘要：目的：探讨二甲双胍和胰岛素治疗妊娠合并糖尿病对母婴结局的影响。方法：选取于2014年9月-2015年9月在我院接受治疗的妊娠合并糖尿病患者共76例，随机分为观察组和对照组，每组各38例。所有患者均进行饮食控制，对照组采用胰岛素治疗，观察组采用二甲双胍治疗。观察治疗效果。结果：观察组子娴前期率为5.3%，体重增加（1.1plusmn;0.3）kg，均优于对照组，组间比较有差异（P＜0.05）；观察组蛋白尿、引产术及剖腹产情况，与对照组相比无显著差异（P＞0.05）；观察组巨大儿发生率为5.3%，低血糖发生率为2.6%，黄疸症发生率为10.5%，均优于对照组，组间比较有差异（P＜0.05）；观察组新生儿畸形、呼吸窘迫情况，与对照组相比无显著性差异（P＞0.05）。结论：二甲双胍能够改善妊娠合并糖尿病患者的妊娠结局，降低孕产妇出现子娴前期的发病率，降低围产儿出现巨大儿、低血糖以及黄疸症并发症的发生率，值得临床推广。 　　关键词：二甲双胍；胰岛素；妊娠合并糖尿病；母婴结局；影响 　　Metformin and insulin treatment of gestational diabetes mellitus on maternal and infant outcomes 　　Abstract Objective To Explore metformin and insulin treatment of gestational diabetes mellitus on maternal and infant outcomes .Methods Selection in September 2014 - September 2015 in our hospital for treatment of pregnancy with a total of 76 patients with diabetes, were randomly divided into observation group and control group, each group 38 cases. All patients to diet control, the control group using insulin treatment, the observation group was treated with metformin. Observed treatment effect. 　　Results Observation group the xian upfront at a rate of 5.3%, weight gain (1.1 + / - 0.3 kg, were superior to control group, there are differences between the comparison between groups (P lt; 0.05); Proteinuria, induction of labor and cesarean section observation group, compared with the control group no significant difference (P gt; 0.05); Observation group of macrosomia incidence was 5.3%, the incidence of hypoglycemia was 2.6%, jaundice disease incidence rate is 10.5%, superior to control group, there are differences between the comparison between groups (P lt; 0.05); Observation group of birth defects, respiratory distress, compared with the control group there was no significant difference (P gt; 0.05). 　　Conclusion Metformin can improve the pregnancy outcome of the pregnancy with diabetes, decrease incidence of maternal son appeared the xian early, to reduce perin