医学论文之实验研究（九）.docVIP

螺旋藻胶囊对气虚和血虚证小鼠作用的实验研究 作者：辛志伟1, 杨 胜1, 张仲林1, 谭正怀3, 马松涛1, 石锦萍2 作者单位：1.成都医学院,成都 610083;2.重庆华森制药有限公司成都华森药物研究所,成都 611731; 【摘要】 目的 探讨螺旋藻胶囊对气虚证小鼠免疫系统和运动耐量的影响及对血虚证小鼠血液系统的改善作用。 方法 用限饲法复制气虚证小鼠模型,用放血法复制血虚证小鼠模型。经连续9 d给小鼠螺旋藻胶囊灌胃后,分别检测气虚证小鼠运动耐量、脾脏指数、胸腺指数和血虚证小鼠的血象。结果 螺旋藻胶囊可显著延长气虚证小鼠的游泳时间,增加其脾脏指数和胸腺指数;显著增加血虚证小鼠白细胞计数、红细胞计数、血红蛋白、红细胞比容及血小板数量。结论 螺旋藻胶囊具有一定的益气养血功效。 【关键词】 螺旋藻胶囊; 气虚证; 血虚证 Empirical study of effects of spirulina capsule on mice with deficiency of vital energy and with hemopeniaXIN Zhiwei1,YANG Shen1,ZHANG Zhonglin1,TAN Zhenghuai3,MA Songtao1,SHI Jinping2(1.Chengdu Medical College,Chengdu 610083,China;2.Chengdu Huasen Institute of Pharmaceutical Research,Chongqing Huasen Tragacanth Limited Company,Chengdu 611731,China;3.Sichuan Institute of Chinese Materia Medica,Chengdu 610041,China)【Abstract】 Objective To investigate the effects of spirulina capsule on immune system and exercise tolerance in mice with deficiency of vital energy and on blood system in mice with hemopenia.Methods We made the animal models of mice with deficiency of vital energy and hemopenia by limiting feed method and depletion method,respectively.After intragastric administration of spirulina capsule for 9 days,the exercise tolerance,splenic index,thymic index of mice with deficiency of vital energy was determined,respectively and the hemogram of mice with hemopenia was also determined.Results The time of swimming in mice with deficiency of vital energy was longer than that in control group,and both splenic index and thymic index increased.Moreover,WBC,RBC,Hb,HCT and PLT of mice with hemopenia also rose.Conclusion Spirulina capsule has some effects of benefiting vital energy and hemogenesis.【Key words】 spirulina capsule; deficiency of vital energy; hemopenia 　　螺旋藻是一种具有极高营养价值和多种药理活性成分的天然物质[1,2]。螺旋藻中蛋白质含量高达57.9%,其中所含的人体必需氨基酸与联合国粮农组织和世界卫生组织所推荐的 RDA值 (人体需要量) 极其相似,分别为异亮氨酸4.1%～4.5%,亮氨酸5.8%～6.8%,赖氨酸4.4%～4.6%,苯丙氨酸2.9%～4.4%,蛋氨酸1.8%～2.4%,苏氨酸2.7%～4.1%,色氨酸1.1%～6%,缬氨酸4.8%～6.5%。另外,它还含有丰富的多糖、维生素、色素、脂肪酸、矿物质等成分。其