花生四烯酸代谢物对呼吸道感受器的作用.pdfVIP

Acta Physiologica Sinica , April 25, 2007, 59 (2): 141-149 141 Brief Review Effects of arachidonic acid metabolites on airway sensors 1 1,2,* LIN Shu-Xin , Jerry YU 1Department of Pulmonary Medicine; 2Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA Abstract: Arachidonic acid (AA) in the cell membrane produces a variety of metabolites by different enzymatic pathways. These lipid metabolites, along with other mediators, play an important role in the inflammatory processes. Many of them can bind directly to the receptors on the sensory endings and initiate electrical impulses to be transmitted to the central nervous system, causing reflex responses. These bioactive AA metabolites may also alter the lung mechanics (mechanical environment of the sensory ending), and in turn, stimulate sensory afferents. In addition, some metabolites may sensitize the sensory endings and make them more responsive to other mechanical or chemical stimulation. These metabolites may also induce other mediators and modulators to cause physiological effects. Furthermore, some of them may attract inflammatory cells to produce a localized effect. In short, AA metabolites may come from different sources and act through multiple pathways to stimulate airway sensors. This brief review is intended to illustrate the underlying mechanisms and help elucidate the inflammatory process in the airways. Key words: airway sensor; vagal afferent; inflammation; arachidonic acid; prostaglandins; lung 花生四烯酸代谢物对呼吸道感受器的作用 1 1,2,* 林树新 ，於 峻 1 2 路易维尔大学 肺内科系； 生理与生物物理系，肯塔基州 40292 ，美国 摘 要：迷走神经与神经- 免疫交互作用密切相关。在呼吸道中，迷走神经传入纤维末梢上的伤害性感受器能被多种细胞 因子、炎性介质和免疫调质激活。在炎症过程中，细胞膜磷脂在磷脂酶A 作用下释放花生四烯酸(arachidonic acid, AA) ，后