卡泊三醇软膏联合氟芬那酸丁酯软膏治疗神经性皮炎和慢性湿疹疗效观察.docVIP

精品论文 参考文献 卡泊三醇软膏联合氟芬那酸丁酯软膏治疗神经性皮炎和慢性湿疹疗效观察 四川省医学科学院?四川省人民医院 四川 成都 610072 　　【摘 要】目的：研究卡泊三醇软膏联合氟芬那酸丁酯软膏治疗神经性皮炎和慢性湿疹的临床效果。方法：从我院2015年2月至2016年1月的神经性皮炎和慢性湿疹患者中抽取102例进行研究，以随机分组法，分为对照组与观察组各51例，给予对照组0.05%卤米松乳膏与0.025%维A酸乳膏，给予观察组卡泊三醇软膏联合氟芬那酸丁酯软膏。观察两组患者的临床效果、症状改善情况、复发及不良反应发生情况。结果：观察组总有效率为90.20%，高于对照组，P＜0.05；观察组治疗后的症状积分为（1.92plusmn;0.34）分，明显优于对照组，P＜0.05；两组均无严重不良反应发生，Pgt;0.05；观察组复发概率（15.69%）较对照组更低，P＜0.05。结论：卡泊三醇软膏联合氟芬那酸丁酯软膏应用于神经性皮炎与慢性湿疹的治疗中，能够明显改善患者症状，且复发概率低，安全性高。 　　【关键词】卡泊三醇软膏；氟芬那酸丁酯软膏；神经性皮炎；慢性湿疹；效果 　　【Abstract】Objective:To study the clinical effect of calcipotriol ointment combined with flufenac n-butyl ointment in the treatment of neurodermatitis and chronic eczema.Methods:From February 2015 to January 2016, 102 patients with neurodermatitis and chronic eczema were randomly divided into control group and observation group (n=51).The control group was given 0.05% Halometasone cream and 0.025% retinoic acid cream were given to the observation group, combined with ketoprofen ointment and flufenac n-butyl ointment. The clinical effect, symptom improvement, recurrence and adverse reaction were observed.Results:The total effective rate of the observation group was 90.20%,higher than the control group,Plt;0.05; the symptom score of the observation group after treatment was (1.92plusmn;0.34) points, significantly better than the control group, Plt;0.05; (Pgt; 0.05). The recurrence rate in observation group was lower than that in control group (P lt;0.05). Conclusion: Kaplotriol ointment combined with flufenac n - butyl ointment can be used in the treatment of neurodermatitis and chronic eczema. It can improve the symptoms of the patients, and the probability of recurrence is low and the safety is high. 　　【Key words】Kaplan Triol Ointment; Flufenac Butyl Ointment; Neurodermatitis; Chronic eczema; Effect 　　【中图分类号】R758.23 【文献标识码】A 【文章编号】2096-0867（2016）15-045-02 　　 　　 　　慢性湿疹与神经性皮炎是慢性皮肤疾病，较为常见[1]，患者易反复发作或迁延不愈，以往多使用糖皮质激素进行外用治疗，能够收获一定效果，但其复发概率高，且不良反应较多，目前临床逐渐利用非激素药物替代激素进行治疗[2]，虽然复发概率大大降低，