参苓白术散联合双岐杆菌四联活菌片治疗小儿抗菌素相关性腹泻的临床观察.docVIP

精品论文 参考文献 参苓白术散联合双岐杆菌四联活菌片治疗小儿抗菌素相关性腹泻的临床观察 侯国华 张荣华（通讯作者） 李丰华 （甘肃省古浪县人民医院儿科 733100） 【摘要】 目的：观察参苓白术散联合双岐杆菌四联活菌片治疗小儿抗菌素相关性腹泻的临床疗效。方法：采用随机对照方法将抗菌素相关性腹泻患儿60例分为2组，治疗组30例，对照组30例；治疗组服用参苓白术散与双岐杆菌四联活菌片，对照组服用双岐杆菌四联活菌片，治疗1周后观察2组临床疗效。结果：2组均有效，治疗组有效率96％，观察组有效率80％，差异有显著性（P＜0.05）。结论：参苓白术散联合双岐杆菌四联活菌片治疗小儿抗菌素相关性腹泻疗效显著，安全性高，值得临床推广。 【关键词】 参苓白术散 双岐杆菌四联活菌片 小儿抗菌素相关性腹泻 【中图分类号】R720.5 【文献标识码】A 【文章编号】2095-1752（2015）33-0187-02 【Abstract】Objective To observe Shenlingbaizhu powder combined Bifidobacterium quadruple live bacteria tablets in the treatment of pediatric antibiotic associated diarrhea clinical curative effect. Methods Using randomized controlled methods antibiotic associated diarrhea in children with 60 cases were divided into 2 groups, 30 cases in the treatment group, 30 cases in the control group. The treatment group taking Shenling Baizhu powder and Bifidobacterium quadruple viable bacteria tablets. Patients in control group were treated with Bifidobacterium quadruple viable films. After 1 week of treatment observation of the clinical curative effect of the 2 groups. Results 2 groups were effective, the effective rate of the treatment group was 96%, the observation group was 80%, the difference was significant (P lt; 0.05). Conclusion Shenlingbaizhu powder combined with Bifidobacterium quadruple live bacteria tablets in the treatment of pediatric antibiotic associated diarrhea curative effect, high safety, it is worth clinical promotion. 【Key words】SHENLINGBAISHU Bifidobacterium Tetravaccine tablets of pediatric antibiotic associated diarrhea 小儿抗菌素相关性腹泻是临床上常见病之一，近年来小儿抗菌素相关性腹泻的发病率明显上升[1]。其主要原因系小儿感染性疾病、非感染性疾病广泛应用广谱抗菌素同时，出现严重的抗菌素相关性腹泻，其临床主要表现为：大便性质改变，次数明显增多。目前常规采用微生态疗法，应用肠粘膜保护剂、适量微量元素、维生素[2]。因此肠粘膜屏障剂和微生态制剂是目前治疗小儿抗菌素相关性慢性腹泻的理想药物。 1.临床资料与方法 1.1 一般资料 60例患儿原发病为支气管肺炎22例，肺炎20例，非典型肺炎8例，上呼吸道感染及急性扁桃体炎10例，且治疗前及治疗后72小时内均无腹泻发生。经抗菌素治疗3～5天后发生腹泻，呈淡黄色稀水样便，有时如蛋花样；随机分为治疗组和对照组。治疗组30例，男16例，女14例，年龄8月～12