吡贝地尔联合尼莫地平治疗一氧化碳中毒迟发性脑病的疗效观察.docVIP

精品论文 参考文献 吡贝地尔联合尼莫地平治疗一氧化碳中毒迟发性脑病的疗效观察 杨会欣 赵灵敏 贾子馨（河北省新乐市医院神经内科 河北新乐 050702） 　　【摘要】目的 观察吡贝地尔联合尼莫地平治疗一氧化碳中毒迟发性脑病的效果。方法　一氧化碳中毒迟发脑病患者100 例，分为治疗组（50 例），对照组（50 例），均给与常规治疗，治疗组同时加用吡贝地尔及尼莫地平，连续治疗8周。治疗8周进行MMSE、HDS-R、ADL评分；治疗前后行心电图、血常规、生化全项检查及记录不良反应。结果　治疗8周后MMSE、HDS-R评分2组均高于治疗前，治疗组优于对照组，差异有统计学意义；8周后ADL评分2组均低于治疗前，治疗组下降幅度高于对照组，差异有统计学意义；治疗前后无心电图、血常规、生化全项检查差异，无不良反应。结论　吡贝地尔联合尼莫地平治疗一氧化碳中毒迟发性脑病效果显著。 　　【关键词】 一氧化碳中毒迟发脑病 多巴胺受体激动剂 吡贝地尔 尼莫地平 　　【中图分类号】R969 【文献标识码】A 【文章编号】1672-5085（2013）34-0081-02 　　【Abstract】Objective: To observe piribedil and nimodipine application in delayed encephalopathy of carbon monoxide poisoning caused on the impact of dystonia. Method: 100 patients of carbon monoxide poisoning delayed encephalopathy, divided into a treatment group (50 cases) and control group (50 cases) were given conventional treatment, the observation group plus piribedil nimodipine continuous treatment 8 weeks. MMSE, HDS-R, ADL score eight weeks of treatment; treatment before and after the electrocardiogram, blood, biochemical full inspection and recording of adverse reactions. Results: After 8 weeks of treatment, MMSE, HDS-R ratings were higher than before treatment, the observation group than the control group, the difference was statistically significant; ADL scores were lower than before treatment, the observation group decreased after 8 weeks higher than those in the control group, the difference was statistically significant; electrocardiogram, blood, biochemical full inspection differences before and after treatment, no adverse reactions. Conclusion: piribedil and nimodipine treatment delayed encephalopathy of carbon monoxide poisoning effect significant. 　　【Key words】 chronic encephalopathy of carbn monoxide poisoning dopamine receptor agonist piribedil nimodipine 　　一氧化碳中毒迟发脑病( chronic encephalopathy of carbn monoxide poisoning , CEOCMP) 是指一氧化碳中毒患者经过积极抢救，在急性中毒症状缓解后经过数天或数周表现正常或接近正常的“假愈期”后，再次出现精神异常、神智不清、锥体系或锥体外系等脑病症状,其