替米沙坦联合尿毒清颗粒治疗早期糖尿病肾病32例.pdfVIP

· l152 · HeraldofMedicineVo1．28No．9September2009 替米沙坦联合尿毒清颗粒治疗早期糖尿病 肾病 32例 王福诩 ，黄卓尧 ，伍军伟’ (广西壮族 自治区桂平市人民医院1．肾内科；2．中医科；3．内分泌科，537200) [摘 要] 目的 探讨替米沙坦联合尿毒清颗粒治疗早期糖尿病肾病的疗效。方法 将64例早期糖尿病 肾病 (DN)患者随机分为对照组和治疗组，每组32例。两组患者均按糖尿病常规治疗，对照组给予替米沙坦40mg·d一，po， qd；治疗组在对照组治疗的基础上联用尿毒清颗粒每次5g，温水冲服，白天3次，睡前 1次，用药间隔不超过8h。疗程 均为6个月。结果 ①与治疗前比较，治疗组治疗后血清总胆固醇(TC)、三酰甘油(TG)明显下降(P0．05)，高密度 脂蛋白(HDL)明显上升(P0．05)，对照组上述指标变化不明显(P0．05)；②两组尿微量清蛋白排泄率(UAER)均显 著改善 (P0．05)。治疗组较对照组疗效更显著(P0．05)，血肌酐(SCr)明显下降(P0．05)，而对照组指标变化不明 显(P0．05)；③两组治疗后空腹血糖 (FBG)、血尿素氮(BUN)、血清蛋白(Alb)均无明显变化(P0．05)。结论 替米 沙坦联合尿毒清颗粒治疗早期糖尿病肾病疗效确切。 [关健词] 替米沙坦；尿毒清颗粒；肾病，糖尿病 [中图分类号] R972．4；R587．2 [文献标识码] A [文章编号] 1004-0781(2009)09—1152-03 TherapeuticEfectsofTelmisartaninCombinationwithUremicClearanceGranuleon 32 CasesofEarlyDiabeticNephropathy WANGFu—xu，HUANG Zhuo—yao，wu Jun—wei(1．DepartmentofNephrology ；2．Departmentof TraditionalChineseMedicine；3．DepartmentofEndocrinology，RenminHospitalofGuiping，Guiping537200， Guangxi，China) ABSTRACT Objective Toinvestigatethetherapeuticeffectsoftelmisartancombinedwithuremicclearancegranuleon earlydiabeticnephropathy(DN)． Methods 64patientswithDNwererandomlyallocatedintotreatmentgroupandcontrol group，32ineach．Patientsincontrolgroupweretreatedwithtelmisartan40mg ‘d～，po，qd；thoseintreatmentgroupwereP．o． administeredwithuremicclearancegranule，basedonconventionaltreatment，5geachtime，3timesondaytime，1timebefore sleepattheintervallessthan8h．Thetreatmentslastedfor6months． Results ①TC，TG，SCrdecreased(P0．05)and HDL—Cincreasedsignificantlyinpatientsaftertreatmentcomparedwiththosebeforetreatment(P0．05)．Therewerenoobvious differencesfoundincontrolgroup．(~)BothgroupsreducedUAERefficiently(P0．05)．Incontrast，thereductionwasrgeaterin treatmentgroup(P0．05)．~Therewasnosignificantchangein