Eph受体家族及其配体的信号转导途径及功能.pdfVIP

498 Prog. Biochem. Biophys. 2001; 28 ( 4) Eph * ** 张晓光 药立波 苏成芝 (, 710032) Eph , Eph ( ephrin) , , Eph , ( patterning), , . Eph , . Eph , ephrin, Q78 ( receptor tyrosine C PDZ (postsynaptic density protein, discs kinase, RTK) large, zona occludens ) [4] . 1987 , irai RTK (motif) . 40 Eph C [1] Eph EphA1 ( SAM , Tyr932 ( , erythropoietinproducing S 2 ) ( hydrophobic core) [ 2] SAM , hepatocellular carcinoma cell line) , Eph [5] 14 , RTK . (1) . . . , Eph ( ephrins) 8. Eph , , , . 1 11 Eph Eph , , EphA EphB . Fig1 The structure and signal pathway of the Eph receptors Eph N 1 Eph (Glb) , ( 20 , Cys) , RTKS, Eph (FN ) , X . Eph , (jellyroll) S 2 , , * , . ** [3] . . Tel: 029337451611, Email: xgzhang@fmmu.edu.cn Eph : : ( TK) , SAM ( sterile alpha motif)[ 4] 2001; 28 ( 4) Prog. Biochem. Biophys. 499 Src ; Grb2, Grb10, Nck, Ras GTPase, PI3K p85 [6] . . SLAP ( S 3S 2 , src [7] ) . SAM S 2 Grb10 Fig2 Th