Eph受体和Ephrin配体的研究进展.pdfVIP

中国癌症杂志2003 13 1 CHINA ONCOLOGY 2003 Vol. 13 No. 1 79 Eph 受体和Ephrin 配体的研究进展 , 综述, 审校 ( , 400042) [ ] , Eph Ephrin [ ] ; ; : R73023 : A : 2003) Recent advances in Eph receptors and Ephrin ligands L UO Chao, TIAN Gang , X UMinhui (Dep artment of Neurosurgery , Third Military Medi al University , Chongqing 400042 , China) [Abstract] Protein tyrosine kinase enes are the lar est family of onco enes. This is not surprisin since protein tyrosine kinases are important components of si nal transduction pathways that control cell shapes, proliferation, differentiation, and mi ration. This review will address the recent pro ress in understandin the function of Eph receptor and ephrin li ands in normal development and how disre ulation of these functions could promote tumori enesis. [ Key words] receptor tyrosine kinase; axon uidance; an io enesis Eph Ephrin 14 节 [ 2] ,Eph Bruckner Eph Eph Ephrin (RTK) , , Eph , , ; Eph Eph : Src Ephrin , , Abl 1996 9 20 LMWPTP( ) ; [ 1] : Ephrin, C3 Ras GTPase ephoros, ; ; SLAPGrb2Grb10 Nck; : ( GPI) SHEP1, RRasRAP1A C EphrinA 5 ; 3 B Eph PDZ( , , Ephrin ) , AF6, Eph : EphA EphB Rap1A ; Pick1, Ephrin Eph , C; Syntenin, syndecan; EphrinA EphA Grip1 Grip2, , EphrinB EphB [ 3] Eph Eph Ephrin , , EphrinB Eph Ephrin [ 2] EphrinB ( 一) Eph 受体和Ephrin 配体参与双向信号调 ,