西尼地平胶囊治疗轻中度原发性高血压的疗效和安全性评价.docVIP

西尼地平胶囊治疗轻中度原发性高血压的疗效和安全性评价 皖南医学院(JofWannanMedicalC,~llege)2006;25(4) .Il床医学? ? 263? 文章编号:100202t7(2006)04—0263—03 西尼地平胶囊治疗轻中度原发性高血压的疗效和安全性评价 王安才,曹蘅,唐军,杨浩,刘文洁,柯永胜,芮世宝,纪勤炯 (皖南医学院附属弋矶山医院fi,内科,安徽芜湖241001)) Efficacyandsafetyevaluationofciinidipine capsuleintreatmentofessentialhypertension WAJWGAn,cai,CAOHeng,TANGL,㈣,YA2,gGHao,LIU Weng-jie.KEYong-sheng,RIShi—bao.jIQingjiong DepartmentofCardiology.YijishanHospital,WananMedicalCollege Wuhu241001.China 【Abstract】Objective:Toevaluatetheefficacyandtolerabilityofeilnidip. inecapsuleintreatmentofmildtomoderateessentialhypertension. Methods:221patientswithmildtomoderateessentialhypertension wererandomlyallocatedtoreceivingeithercilnidipinecapsule5mg/dor cilnidipinetablet5mg/din6hospitals,whichcouldbeincreasedto10 mg/difbloodpressurecontrolwasnot~tisfactory.Sittingposition bloodpressurewastakenandallthesideeffectswererecordedthrough- Outtherapy.24h-ambulatorybloodpressurewasmonitoredinotherhy— pertensivepatients(49).Results:Bothcilnidipinecapsuleandoil— nidipinetabletwereeffectiveforloweringbloodpressure.90.7%and 81.5%ofthepatientsineachgroupwereconsideredtoimprovein8 weekswithnosignificantstatisticaldifferencebetweenthetwogroups Ambulatorybloodpressuremonitoringofcilnidipinecapsuleshowedthat T/Pofdiastolicbloodpressureandsystolicbloodpressurewas58%and 61%respectively.Bothdrugswerewelltolerated,Conclusion:Cilni— dipinecapsuleisveryeffectiveintreatmentofmildtomoderateessential hypertensioninadailydoseof5～10mgwithgoodtolerability. 【Keywords】cilnidipinecapsule;cilnidipinetablet:hypertension; heartratP 【摘耍】目的:评价西尼地平胶囊治疗轻中度原发性高血压 的疗效和安全性.方法:采用多中心,随机双盲法将221例 轻中度原发性高血压患者分为西尼地平胶囊组和西尼地平 片组,分别接受西尼地平胶囊5mg/d或西尼地平片5mg/d 治疗.各中心按病例入选顺序依次使用所分配的药物编号. 2,4和6周时若舒张压≥90mmHg,则剂量加倍,共8周. 治疗前后测量坐位血压,记录所有不良反应.另有49例病 人行24h动态血压监测,观察西尼地平胶囊或西尼地平片 对血压波动的影响.结果:西尼地平胶囊与西尼地平片均能 有效降低血压,治疗总有效率分别为9O.7%和81,5%(Pgt; 0.05),两组降压程度无统汁学意义(Pgt;0.05).24h动态 收稿日期:2006.05.10 作者简介:王安才(1956.),男,安徽芜湖人.博士,教授,主任医师,硕 士生导师.(电话)055357393l3.(电子信箱)yjswac@sina. com. 血压监测显示西尼地平胶囊组舒张压和收缩压的降压T/