2型糖尿病血尿酸与血脂altcrp及胱抑素c关系的临床研究张洪艳.docVIP

2型糖尿病血尿酸与血脂、ALT、CRP及胱抑素C关系的临床研究 张洪艳1,2 马建慧2 周健2 孙永宁2* （1、成都中医药大学 成都 610075 2、上海交通大学附属第六人民医院 上海200233） 【摘要】目的：探讨2型糖尿病患者血清尿酸与血脂、丙氨酸转移酶（ALT）、C反应蛋白及胱抑素C的关系。方法：选取无并发症的2型糖尿病门诊及住院患者160例，按照血清尿酸水平分为4组：第1组UA250umol/L，第2组UA 250-300ummol/L，第3组300-350ummol/L，第4组UA 350ummol/L。测量身高、体重、腰围、臀围，计算体重指数（BMI=体重（KG）/身高2（m2）。禁食8小时测定空腹血糖，餐后30分钟血糖，餐后120分钟血糖，血脂、糖化血红蛋白（HBA1C））））））Clinical research on relationship between uric acid and blood lipid /CRP/and Cystatin C in T2DM Hongyan ZHANG1,2 ，Jianhui MA2 ，Jian ZHOU2 ，Yongning SUN2 (1.Chengdu university of traditional Chinese medicine Chengdu 610075 2. Shanghai Jiaotong university affiliated sixth people”s hospital Shanghai 200233) [ABSTRCT] Objective: to investigate the relationship between serum uric acid(UA) and blood lipid ,alanine transferase (ALT), C-reactive protein and Cystatin C in type 2 diabetes mellitus(T2DM). Methods: To select 160 T2DM patients without complications both from inpatients and outpatients, who were divided into 4 groups according to level of UA: group 1:UA250umol/L, group 2 UA250-300ummol/L, group 3:UA 300-350ummol/L, group4:UA350ummol/L. Measuring height, weight, waist circumference and hip circumference, calculating body mass index (BMI=weight(kg)/height2(m2)). Forbidden food for 10 hours , fasting blood glucose, 30min postprandial blood glucose and 120 min postprandial blood glucose, lipids, Glycosylated hemoglobin, glycated albumin, serum alanine transferase (ALT), high sensitivity C-reactive protein (CRP) and Cystatin-C were measured. Correlation was made between UA and blood lipid, ALT, CRP and Cystatin-C. Meanwhile, according to gender, stepwise multiple regression analysis was made to explore factors influencing UA. Results：Cystatin C /C-reactive protein/ triglycerides were all positively correlated with UA（r=0.751,P=0.048;r=0.162,P=0.041;r=0.251,P=0.03）;And in female patients, Cystatin C /C-reactive protein were positively correlated with UA(（r=0.413,P=0.004）（r=0.31,P=