中医药防治糖尿病心肌纤维化机制研究进展-中国中医药信息杂志.PDFVIP

·124· Chinese Journal of Information on TCM May 2017 Vol.24 No.5 综述 中医药防治糖尿病心肌纤维化机制研究进展 1,2 2 岳星星 ，谢春毅 1.上海中医药大学，上海 201203 ；2.上海中医药大学附属上海市中西医结合医院，上海 200082 摘要：糖尿病心肌纤维化主要发生在糖尿病心肌病晚期，与该病的高死亡率密切相关。研究表明，现代医 学对本病尚缺乏特效治疗药物，中医药在防治糖尿病心肌纤维化方面优势逐渐显现，其干预机制主要涉及肾素- 血管紧张素-醛固酮系统、氧化应激、血管内皮活性、炎症反应、细胞外基质的动态平衡、细胞凋亡和细胞因 子的调节等方面。本文对近年来中医药防治糖尿病心肌纤维化的机制研究进展进行综述，为临床防治糖尿病心 肌纤维化提供依据。 关键词：糖尿病心肌病；心肌纤维化；作用机制；中医药；综述 DOI：10.3969/j.issn.1005-5304.2017.05.031 中图分类号：R259.872 ；R259.422 文献标识码：A 文章编号：1005-5304(2017)05-0124-05 Research Progress in Mechanism of Prevention and Treatment of Diabetic Myocardial Fibrosis with TCM YUE Xing-xing1,2, XIE Chun-yi2 (1. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 2. Shanghai TCM-Integrated Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China) Abstract: Diabetic myocardial fibrosis mainly occurrs at late stage of diabetic cardiomyopathy, which is closely associated with the high mortality of this disease. Studies have shown that this disease is lack of specific treatment medicine, while the advantages of TCM in prevention and treatment of diabetic myocardial fibrosis are increasingly significant. The intervention mechanism mainly involves renin-angiotensin-aldosterone system, oxidative stress, endothelial activity, inflammation response, the dynamic balance of extracellular matrix, cell apoptosis, regulation of cytokines and other aspects. This article reviewed the research progress in mechanism of prevention and treatment of TCM for diabetic myocardial fibrosis, with a purpose to provide scientific basis for prevention and treatment of diabetic myocardial fibros