基于关节超声评价独活寄生汤治疗肝肾亏虚型膝关节骨性关节炎临床.PDFVIP

·18· Chinese Journal of Information on TCM Jan.2015 Vol.22 No.1 基于关节超声评价独活寄生汤治疗肝肾亏虚型 膝关节骨性关节炎临床疗效 周小莉,邵勤,张莹,肖芳 重庆市中医院,重庆 400021 摘要：目的 基于关节超声评价独活寄生汤治疗肝肾亏虚型膝关节骨性关节炎 (KOA)的近期临床疗效。 方法 将 120例肝肾亏虚型 KOA 患者随机分为 2 组,每组 60 例。对照组予盐酸氨基葡萄糖胶囊口服,治疗组在 对照组治疗基础上加用独活寄生汤,均治疗 8 周。观察 2 组 KOA 患者治疗前后红细胞沉降率(ESR)、C 反应蛋 白(CRP)、WOMAC 评分、关节肿胀积分、中医证候评分变化,采用高频关节超声监测 2 组患者治疗前后膝关节髌 上囊积液、滑膜厚度、软骨及骨质破坏、滑膜血流信号声像图的变化特征。结果 治疗组在改善WOMAC 评分、 关节肿胀积分、中医证候评分等方面较对照组有明显优势,差异有统计学意义(P ＜0.05,P ＜0.01)；治疗后患 者关节腔积液减少,膝关节滑膜厚度变薄,关节滑膜血流信号减少(P ＜0.05,P ＜0.01)。结论 独活寄生汤治疗 肝肾亏虚型 KOA 临床效果显著。超声可以清晰地观察 KOA 患者关节腔积液、滑膜厚度、滑膜血流信号等改变, 为临床药物治疗 KOA 提供较好的影像学评价依据。 关键词：独活寄生汤；膝关节骨性关节炎；肝肾亏虚；超声 DOI：10.3969/j.issn.1005-5304.2015.01.006 中图分类号：R272.968.4 文献标识码：A 文章编号：1005-5304(2015)01-0018-04 Efficacy Evaluation of Duhuo Jisheng Decoction in Treating Knee Osteoarthritis with Liver and Kidney Deficiency Syndrome by Ultrasound ZHOU Xiao-li, SHAO Qin, ZHANG Ying, XIAO Fang (Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China) Abstract ：Objective To evaluate the clinical efficacy of Duhuo Jisheng Decoction in treating liver and kidney deficiency syndrome of knee osteoarthritis (KOA) by ultrasound. Methods A total of 120 cases of KOA patients with liver and kidney deficiency syndrome were randomly divided into two groups (each contains 60 cases). Control group took hydrochloric acid glucosamine capsules, while treatment group took Duhuo Jisheng Decoction additionally for 8 weeks. ESR, CRP, WOMAC, joint swelling scores, and TCM syndrome scores of the two groups were determined, and the sonographic characteristics of knee-joint effusion in patellar fabricius, synovial membrane, cartilage and bone erosions