治疗帕金森病的药物.PPTVIP

* (2) MAO-B inhibitors (＝BBB) L-DOPA DA AADC COMT 3-OMD L-DOPA 3-OMD DA AADC X degradation MAO-B COMT reuptake ( 3-O-甲基多巴) BBB Brain Periphery compete Carrier * Selegiline (司来吉兰) BBB permeable, inhibit MAO-B: CNS reduce L-dopa dose and “on-off phenomena” low dose (＜10mg/d) —only inhibit MAO-B→DA↑ high dose (＞10mg/d)—inhibit MAO-A, too→ hypertensive crisis antioxidant effect * X * (3) COMT inhibitors (≠or＝ BBB) L-DOPA DA AADC COMT 3-OMD L-DOPA 3-OMD DA AADC X degradation MAO-B COMT reuptake ( 3-O-甲基多巴) BBB Brain Periphery compete Carrier * Periphery: CNS: DA degradation↓