尿NAG检测对早期肾损害的诊断价值.docVIP

精品论文 参考文献 尿NAG检测对早期肾损害的诊断价值 李耀芳（河南省舞钢市人民医院 462500） 　　【摘要】目的 探讨尿N-乙酰-beta;-D-氨基葡萄糖苷酶（NAG）检测对早期肾损害的诊断价值及临床意义。方法　分别对我院340例住院患者和40例健康体检者进行尿NAG、尿微量白蛋白（MALB）、beta;2-微球蛋白（beta;2-MG）、alpha;1-微球蛋白（alpha;1-MG）检测。结果　340例住院患者中124例患者标本NAG检测结果显著高于健康对照组；87例患者标本beta;2-MG检测结果显著高于健康对照组；64例患者标本alpha;1-MG检测结果显著高于健康对照组；46例患者标本MALB检测结果显著高于健康对照组。结论　尿NAG检测对于早期肾损害的灵敏度优于尿beta;2-MG、尿alpha;1-MG和尿MALB。对于临床早期发现患者肾损害有一定提示作用，值得临床推广。 　　【关键词】尿N-乙酰-beta;-D-氨基葡萄糖苷酶 早期肾损伤 　　【中图分类号】R446.12 【文献标识码】A 【文章编号】2095-1752（2013）31-0150-02 　　Diagnostic value of urinary NAG in early renal injury 　　YAO-FANG LI 　　Wu Gang city Peoplersquo;s hospital clinical laboratory of He Nan province 　　【Abstract】Objective: To explore diagnostic value of urinary NAG in early renal injury . Methods: 340 cases in our hospital patients and 40 healthy subjects for urinary NAG, urinary albmin(MALB),beta;2-microglobulin(beta;2-MG),a1-microglobulin(a1-MG) detection. Results:In 340 cases of hospitalized patients, 120 patients specimens NAG test results were significantly higher than the healthy controls group; 87 patients specimensbeta;2-MG test results were significantly higher than the healthy controls group; 64 patients specimens a1-MG test results were significantly higher than the healthy controls group; 46 patients specimens MALB test results were significantly higher than the healthy control group. Conclusion: Urinary NAG detection sensitivity for early renal damage than urinary beta;2-MG, urinary a1-MG and urine MALB. For clinical renal damage in patients with early detection of certain suggestive, worthy of promotion . 　　【Key】Urinary NAG Early renal injury 　　随着肾脏疾病发病率患者的不断增长，肾脏疾病已成为全球面临的公共健康问题。肾脏疾病患者在出现明显临床症状之前，存在较长的无症状阶段，不通过筛查，很难发现相对早期的肾脏疾病患者。而急性肾损伤有较高的发病率和死亡率，在普通人群中约为0.5%～1.0%，在住院患者中为2.0%～7.0%[1]。因此，如何发现早期肾损伤对于临床医生至关重要。有文献报道，尿微量白蛋白（MALB）、尿a1-微球蛋白（a1-MG）、尿beta;2-微球蛋白（beta;2-MG）、尿N-乙酰-beta;-D-氨基葡萄糖苷酶（NAG）检测能反映早期肾功能损害程度[2]。本文对340例住院患者标本和40例健康体检者标本进行上述4项指标检测，结果如下： 　　1 资料与