乳腺癌1721.ppt

Regional Lymph Nodes (N) Pathologic (pN) a pN0(i–) No regional lymph node metastasis histologically, negative IHC pN0(i+) No regional lymph node metastasis histologically, positive IHC, no IHC cluster greater than 0.2 mm pN0(mol–) No regional lymph node metastasis histologically, negative molecular findings (RT-PCR) pN0(mol+) No regional lymph node metastasis histologically, positive molecular findings (RT-PCR) Regional Lymph Nodes (N) a Classification is based on axillary lymph node dissection with or without sentinel lymph node dissection. Classification based solely on sentinel lymph node dissection without subsequent axillary lymph node dissection is designated (sn) for “sentinel node,” e.g., pN0(i+) (sn). b RT-PCR: reverse transcriptase/polymerase chain reaction. Regional Lymph Nodes (N) pN1 Metastasis in 1 to 3 axillary lymph nodes, and/or in internal mammary nodes with microscopic disease detected by sentinel lymph node dissection but not clinically apparent** pN1mi Micrometastasis (greater than 0.2 mm, none greater than 2.0 mm) pN1a Metastasis in 1 to 3 axillary lymph nodes pN1b Metastasis in internal mammary nodes with microscopic disease detected by sentinel lymph node dissection but not clinically apparent** pN1c Metastasis in 1 to 3 axillary lymph nodes and in internal mammary lymph nodes with microscopic disease detected by sentinel lymph node dissection but not clinically apparent.** (If associated with greater than 3 positive axillary lymph nodes, the internal mammary nodes are classified as pN3b to reflect increased tumor burden) Regional Lymph Nodes (N) Pathologic (pN) a pN2 Metastasis in 4 to 9 axillary lymph nodes, or in clinically apparent* internal mammary lymph nodes in the absence of axillary lymph node metastasis pN2a Metastasis in 4 to 9 axillary lymph nodes (at least one tumor deposit greater than 2.0 mm) pN2b Metastasis in clinically apparent* internal mammar