医学生物学研究所健康人群甲型肝炎病毒抗体水平调查及分析.docVIP

医学生物学研究所健康人群甲型肝炎病毒抗体水平调查及分析 谭振国 罗芳宇 杨蓉 俞泽煦 龙润乡 中国医学科学院医学生物学研究所 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 了解医学生物学研究所健康人群抗甲型肝炎病毒抗体 (抗HAV) 水平, 为制定防制措施提供科学依据。方法 采集职工体检血清标本419份, 采用酶联免疫吸附实验 (ELISA法) 对血清中抗HAV进行检测。结果 职工HAV抗体总阳性率达83.3%;51岁年龄组阳性率最高, 为95.8%, 2230岁组阳性率最低, 为73.1%;从事甲肝疫苗生产及相关人员抗HAV阳性率为83.3%, 与生产无关人员抗HAV阳性率为82.7%;男性抗HAV阳性率为85.7%, 女性抗HAV阳性率为81.0%。结论 HAV抗体阳性率随着年龄增长呈上升趋势, 性别和工种无差别。建议对30岁的年轻职工进行HAV疫苗接种, 以提高这部分人员的整体免疫水平。 关键词： 甲型肝炎病毒; 抗-HAV; 抗体水平; 作者简介：谭振国 (1977-) , 男, 主管技师, 研究方向:微生物学 作者简介：龙润乡, E-mail:runxianglong@ 收稿日期：2017-04-20 基金：云南省重点新产品开发计划项目 (2012BC006) Analysis on anti-HAV level in healthy population in Institute of Medical Biology, Chinese Academy of Medical Sciences TAN Zhenguo LUO Fangyu YANG Rong YU Zexu LONG Runxiang Institute of Medical Biology, Chinese Academy of Medical Sciences; Abstract： Objective To understand the anti-HAV level in healthy population in our department and to provide scientific evidence for preventative measures. Methods A total of 419 serum samples were collected during staff medical examination. Anti-HAV level in serum sample was detected by ELIASA. Results The overall HAV antibody positive rate was 83. 3%; the highest rate was observed in the group of over 51 years old; the lowest rate was found in the group of 22 ~ 30 years old as 73. 1%; the HAV antibody positive rate in individuals from HAV production both directly or indirectly was 83. 3%, and 82. 7% for the people with no involvement; the positive rates for male and female were 85. 7% and 81. 0% respectively. Conclusion The HAV antibody positive rate was increased with aging, meanwhile was not different in gender and type of work. Suggesting to begin the HAV vaccination in youth staffs lower than 30 years old in order to enhance the overall immunologic function. Keyword： Hepatitis A virus; Anti-HAV; Antibody level; Received： 2017-04-20 甲型病毒性肝炎 (以下简称甲肝) 是一种由甲型肝炎病毒 (Hepatitis A virus, HAV) 引起的常见急性肠道传染病。甲肝属于法定传染病中乙类传染病, 其传染性较