总免疫球蛋白E检测在婴幼儿喘息性疾病诊断中的临床意义.docVIP

精品论文 参考文献 总免疫球蛋白E检测在婴幼儿喘息性疾病诊断中的临床意义 刘巧敏（河南省舞钢市人民医院 462500） 【摘要】目的 探讨总免疫球蛋白E（TIgE）检测在婴幼儿喘息性疾病诊断中的临床应用价值。方法　采用微粒子化学发光法对在我院儿科住院的460例婴幼儿喘息性疾病患儿和40例健康儿童进行TIgE检测。结果　在460例婴幼儿喘息性疾病患儿中有42例患儿TIgE结果显著升高。对42例TIgE结果异常患儿标本进行特异性免疫球蛋白E（SIgE）检测，其中34例患儿标本SIgE结果显著升高；8例SIgE结果无显著变化。但临床对42例患儿在原有治疗方案中增加脱敏治疗后都取得了显著的临床疗效。结论　对婴幼儿喘息性疾病进行TIgE检测，有助于临床诊断婴幼儿喘息性疾病是否存在呼吸道变态反应，以便临床采取有效的治疗手段。 【关键词】总免疫球蛋白E（TIgE） 特异性免疫球蛋白E（SIgE） 呼吸道变态反应 【中图分类号】R446.6 【文献标识码】A 【文章编号】2095-1752（2013）30-0025-02 Detection of total IgE in diagnosis of wheezing diseases in infants for clinical significance Qiao-min LIU Wu Gang city Peoplersquo;s hospital clinical laboratory of He Nan province 【Abstract】Objective To investigate detection of total immunoglobulin E (TIgE) in diagnosis of wheezing diseases in infants for clinical significance. Methods 460 cases of infants with wheezing diseases from our hospital pediatric inpatient and 40 cases of healthy children were detected TIgE by using microparticle chemiluminescence . Result 42 children patientsrsquo; total IgE results signify-cantly increased in 460 case of wheezing diseases in infants . 32 children patientsrsquo; specific immunoglobulin E (SIgE) results significantly increased in 42 cases of TIgE results significantly increased. Others 8 cases of SIgE results no significantly changed. But to 42 children with TIgE results rising add desensitization therapy in original treatment clinical effect is remarkable. Conclusion: TIgE were detected for diagnosis of wheezing diseases in infants . Which is helpful to clinical diagnosis whether there are respiratory allergic reaction in diagnosis of wheezing diseases in infants . So that the clinical take effective treatments. 【keywords】Total immunoglobulin E Specific immunoglobulin E Respiratory allergic reaction 小儿喘息性疾病是儿科常见的小气道疾病,如何早期诊断和治疗是目前临床工作难点。已有研究证明，小儿喘息性疾病与免疫球蛋白E（IgE）关系密切[1]，且血清总IgE越高，喘息发作越频繁[2]。本研究意在通过采用微粒子化学反光法检测患儿血清TIgE和荧光酶联免疫反应检测特异性免疫球蛋白E。并对二者关联性进行比较，以探讨血清T