儿童恶性血液病并发毛细血管渗漏综合征的危险因素分析.PDFVIP

·606 · doi 10.3969/j.issn. 1673-4254.2015.04.30 J South Med Univ, 2015, 35(4): 606-609 临床研究 儿童恶性儿童恶性血液病并发毛细血管渗漏综合征的危险因素分析血液病并发毛细血管渗漏综合征的危险因素分析 1 2 3 4 任 颖 ，刘 述 ，杨月明 ，刘洪军 1 2 皖南医学院附属弋矶山医院儿科，安徽 芜湖 241001 ；中山大学中山医学院人体解剖教研室，广东 广州 3 4 510080 ；大连市妇女儿童医疗中心儿童血液肿瘤科，辽宁 大连 116000；安徽医科大学附属安徽省立医院儿 科，安徽 合肥 230001 摘要：目的探讨儿童恶性血液病并发毛细血管渗漏综合征（CLS）发生的危险因素，提高对儿童恶性血液病并发毛细血管渗漏 综合征的临床认识。方法 采用30 例儿童恶性血液病发生CLS 患儿的临床资料，对CLS 发生的高危因素进行多元logistic 回归 分析。结果 在0.05 检验水准下，有无低氧血症，有无败血症与应变量之间的联系有统计学意义，CLS 前白细胞数目，有无严重 骨髓抑制在检验水准附近。结论 毛细血管渗漏综合征为儿童恶性血液病治疗过程中的少见急重症，低氧血症和败血症是儿童 恶性血液病并发CLS 的危险因素，儿内科医师应引起重视。 关键词：儿童恶性血液病；毛细血管渗漏综合征；危险因素 Risk factors for capillary leak syndrome in children with hematological malignancies 1 2 3 4 REN Ying , LIU Shu , YANG Yueming , LIU Hongjun 1Department of Pediatrics, Yijishan Hospital, Wannan Medical College, Wuhu 241001, China; 2Department of Anatomy, Sun Yat-sen University, Guangzhou 510080, China; 3Department of Pediatric Hematological Oncology, Women and Childrens Medical Center, Dalian 116000, China; 4Department of Pediatrics, Anhui Provincial Hospital, Hefei 230001, China Abstract: Objective To investigate the risk factors for capillary leak syndrome (CLS) in children with malignant hematologic diseases. Methods Thirty children with hematological malignancies complicated with CLS were analyzed with multiple logistic regression analysis. Results At the test level of 0.05, hypoxemia and septicemia were found to significantly correlate with CLS in these children, and the number of white blood cells before CLS and severe bone marrow suppression were near the test level. Conclusion Hypoxemia and septicemia are risk factors for CLS in children with malignant hematologic