探讨肠道益生菌在肝硬化治疗中的临床疗效观察.docVIP

精品论文 参考文献 探讨肠道益生菌在肝硬化治疗中的临床疗效观察 五常市五常镇卫生院 150200 【摘 要】目的：研究分析临床上肠道益生菌在肝硬化治疗中的效果。方法：此次研究的对象是选择2013年2月～2014年3月期间在我院治疗的50例肝硬化患者，将其临床资料进行回顾性分析，并作为研究组。肝硬化患者采用三联活菌治疗，治疗20天。观察研究组肝硬化患者血氨及血内毒素的变化。选取50例正常人群作为对照组，研究记录对照组肠道菌群的数量。结果：研究组肝硬化患者菌群明显失调，双歧杆菌、肠杆菌、肠球菌数量比对照组明显要少，通过治疗后，双歧杆菌（10.15plusmn;1.04）数量明显比治疗前数量增多（Plt;0.05），血氨水平降低，患者血浆内毒素水平也得到了明显下降。结论：肝硬化患者的肠道杆菌明显失调，而肠道益生菌能帮助肝硬化患者调节体内菌群，帮助患者降低血氨及血内毒素。 【关键词】肠道益生菌；肝硬化；血氨；血内毒素；双歧杆菌 [Abstract] Objective：To study the effect of probiotics in the treatment of liver cirrhosis. Methods：the study was conducted in 50 patients with cirrhosis who were treated in our hospital from February 2013 to March 2014. The clinical data were retrospectively analyzed. Patients with liver cirrhosis were treated with triple viable bacteria for 20 days. Change of blood ammonia and endotoxin in patients with cirrhosis of liver cirrhosis. 50 normal people were selected as control group，and the number of intestinal flora in control group was recorded. Results：Study Group in patients with liver cirrhosis bacteria group significant dysregulation，Bifidobacterium，Enterobacter and Enterococcus was much less than in the control group，after treatment，the number of bifidobacteria（10.15 + 1.04）significantly than before treatment，increase in the number of（P lt; 0.05），reduce the level of blood ammonia，plasma endotoxin level in patients with has also been significantly decreased. Conclusion：intestinal bacillus in patients with liver cirrhosis is obviously disorders，and intestinal probiotics can help patients with cirrhosis to regulate the body of bacteria，to help patients to reduce blood ammonia and blood endotoxin. [Key words] intestinal probiotics；liver cirrhosis；blood ammonia；endotoxin；Bacillus 肝硬化在临床上是比较常见的慢性进行性肝病，按病因可分为酒精性肝硬化、病毒性肝炎肝硬化、代谢性肝硬化、毒物和药物性肝硬化、隐源性肝硬化等[1]。我国大多数以肝炎后肝硬化居多，也有少部分是酒精肝硬化或血吸虫肝硬化[2]。本次主要是研究肠道益生菌在肝硬化治疗中的作用，研究具体内容如下： 1基线资料和检测方法 1.1基线资料 选取在我院进行治疗的肝硬化患者50例（2013年2月～2014年3月期间），作为研究对象。所有患者均通过科学检测，确诊患有肝硬化。 将这50例肝硬化患者作为研究组，选取50例正常人群作为对照