探讨舒血宁注射液对不稳定型心绞痛患者血清BNP、hs—CRP和颈动脉粥样硬化斑块的影响.docVIP

精品论文 参考文献 探讨舒血宁注射液对不稳定型心绞痛患者血清BNP、hs—CRP和颈动脉粥样硬化斑块的影响 黑龙江省齐齐哈尔市第二医院 161000 【摘 要】目的 评价舒血宁注射液对不稳定型心绞痛患者血清脑钠肽（BNP）、高敏C反应蛋白（hs-CRP）和颈动脉粥样硬化斑块的影响。方法 100例不稳定型心绞痛患者，随机分成观察组和对照组两组。对照组采用常规用药；观察组在对照组治疗方式的基础上，加用舒血宁注射液治疗。结果 治疗两周后，观察组总有效率为90.00%高于对照组总有效率72.00%，具有显著性差异（P lt; 0.05）。治疗两周后，观察组的血清BNP及hs-CRP为（77.2plusmn;23.9）ng/L、（6.0plusmn;2.9）mg/L均低于对照组血清BNP（101.4plusmn;22.5）ng/L、hs-CRP（9.5plusmn;3.4）mg/L，差异均有统计学意义（P lt; 0.01）。治疗两周后，观察组斑块大小、斑块厚度及IMT分别为（0.06plusmn;0.01）cm2、（1.84plusmn;0.46）mm、（1.29plusmn;0.64）mm均低于对照组斑块大小（0.07plusmn;0.02）cm2、斑块厚度（2.02plusmn;0.41）mm及IMT（1.58plusmn;0.62）mm，差异有统计学意义（P lt; 0.05）。结论 舒血宁注射液用于治疗不稳定型心绞痛患者疗效可靠，不但能有效改善不稳定型心绞痛患者的血清BNP、hs-CRP水平，还能明显改善患者的斑块大小及斑块厚度，对不稳定型心绞痛具有一定的阻断和逆转作用。 　　【关键词】舒血宁注射液；不稳定型心绞痛；脑钠肽；高敏C反应蛋白；颈动脉粥样硬化斑块 [Abstract] Objective To evaluate the effect of Shuxuening Injection on serum brain natriuretic peptide in patients with unstable angina pectoris（BNP），high sensitive C reactive protein（hs-CRP）and carotid atherosclerosis. Methods 100 cases of unstable angina patients were randomly divided into observation group and control group，two groups. The control group was treated with routine medication；the observation group in the control group based on the treatment，combined with Shuxuening injection. Results after two weeks treatment，the total effective rate of the observation group was 90% higher than that of the control group，the total effective rate was 72%，with significant difference（P lt; 0.05）. After two weeks of treatment，observation of serum BNP and the hs-CRP group（77.2 + 23.9），ng/L（6 + 2.9）mg/L were lower than the control group of serum BNP（101.4 + 22.5）ng/L，hs-CRP（9.5 + 3.4）mg/L，the differences were statistically significant（P lt; 0.01）. After two weeks of treatment，the observation group plaque size，thickness and IMT were（0.06 + 0.01），cm2（1.84 + 0.46），mm（1.29 + 0.64）mm were lower than the control group（0.07 + 0.02）patch size cm2，plaque thickness（2.02 + 0.41）mm and IMT（1.58 + 0.62）mm，the difference was statistically significant（P lt;