探讨长效胰岛素结合口服降糖药治疗新诊断２型糖尿病６０例的临床疗效.docVIP

精品论文 参考文献 探讨长效胰岛素结合口服降糖药治疗新诊断２型糖尿病６０例的临床疗效 焦惠媛子 武警新疆总队昌吉支队卫生队　新疆　昌吉　８３１１００ 　　【摘要】　目的　探讨分析长效胰岛素联合口服降糖药治疗新诊断２型糖尿病的临床疗效.方法　选取１２０例２型糖尿病患者,随机分为对照组和观察组各６０例,对照组患者采用口服降糖药(二甲双胍和格列美脲)进行治疗,观察组患者在对照组的基础上加用长效胰岛素来得时皮下注射治疗,治疗１２周后观察并记录两组的空腹血糖、餐后２h血糖及糖化血红蛋白(HBA１c).结果　１２０例患者治疗后,患者空腹血糖、餐后２h血糖及糖化血红蛋白(HBA１c)均明显下降,观察组的空腹血糖、餐后２h血糖及糖化血红蛋白(HBA１c)下降水平大于对照组,两组差异具有统计学意义(P＜０．０５).结论　采用长效胰岛素联合口服降糖药治疗新诊断２型糖尿病,能够及时改善患者血糖指标,维持血糖平衡,提升患者的治疗效果,保障患者的生命健康. 【关键词】　长效胰岛素;口服降糖药;２型糖尿病【Abstract】　Objective:Toinvestigatetheclinicalefficacyoflong－actinginsulincombinedwithoralhypoglycemicagentsinpatientswithnewlydiagnosedtype２diabetes．Methods:atotalof１２０patientswithtype２diabetesmellitus,wererandomlydividedascontrolgroupandobservationgroup,eachgrouphad６０cases．Inthecontrolgroupweretreatedwithoralhypoglycemicagents(metforminandglimepiridetreatment,theobservationgrouponthebasisofthecontrolgroupwithlong－actinginsulinLantussubcutaneousinjectiontreatment,１２weeksoftreatment,observeandrecordthetwogroupsoffastingbloodglucose,postprandial２Hbloodglucoseandglycosylatedhemoglobin(HBAincreaseof１inC)．Results:１２０casesofpatientsaftertreatment,patientsfastingbloodgluＧcose,postprandial２Hbloodglucoseandglycosylatedhemoglobin(１intheHBAtendingtoc)wereobviouslydecreased．Intheobservationgroup,thefastingbloodglucose,postprandial２hoursbloodglucoseandglycosylatedhemoglobin(１inHbAtendingtoc)declinelevelgreaterthanthecontrolgroup,thedifferencebetweenthetwogroupswithstatisticalsignificance(P ＜０．０５)．Conclusion:usinglong－actinginsulincombinedwithoralantidiabeticdrugtherapyinnewlydiＧagnosedtype２diabetes,caninatimelymannertoimprovebloodglucosetargets,maintainglucosehomeostasis,andimprovepatientoutcomes,toprotectthepaＧtient＇s【Kliefyeawnodrdhse】alth． 　Long－actinginsulin;oralhypoglycemicdrugs;type２diabetesmellitus【中图分类号】R４５３ 【文献标识码】B 　　【文章编号】１００８－６３１５(２０１５)１２－０６８８－０１　　 　　２型糖尿病又名成人发病型糖尿病,３５岁以后比较多发,超过９０％的糖尿病患者是２型糖尿病[１].传统治疗２型糖尿病主要采取口服降糖药的干预措施,在无法取得良好效果时递增使用胰岛素进行治疗.目前,采用胰岛素对新诊断２型糖尿病患者进行早期治疗,疗效显著[２].本文探讨分析了长效胰岛素联合口服降糖药治疗新诊断２型糖尿病的治疗效果,取得了良好的效果,现报道如下.