探讨阿尔茨海默病与胰岛素抵抗及胰岛β细胞功能的相关性.docVIP

精品论文 参考文献 探讨阿尔茨海默病与胰岛素抵抗及胰岛β细胞功能的相关性 刘羲圣 　　（广东省惠州市惠城区三栋镇卫生院 516025） 　　【摘要】目的 探讨阿尔茨海默病(Alzheimers disease,AD)与胰岛素抵抗及胰岛beta;细胞功能的相关性，以提高对AD患者的治疗疗效。方法：以60例AD患者作为实验观察对象,并且严格按照GDS将患者分为轻、中、重度三种不同程度的患者，再选40个同龄正常的人作为对照比较。然后用化学发光法和葡萄糖氧化酶法对两组人群进行血糖和胰岛素水平的检测。并且计算出他们体内胰岛素抵抗指数。结果：与正常人相比,AD患者空腹状态下体内胰岛素均是上升的,并且胰岛素抵抗指数都高于正常组。AD患者空腹胰岛素平均含量为98.16plusmn;10.28pmol/L,其中轻度组为108.47plusmn;10.39pmol/L；中度组为94.03plusmn;6.06pmol/L；重度组为93.68plusmn;6.38pmol/L而对照组平均含量仅为68.89plusmn;13.89pmol/L两组相比较得出的差异具有统计学意义即Plt;0.05。HOMA2-IR:LOAD观察组为3.14plusmn;0.16,其中轻度组为3.28plusmn;0.08,中度为3.18plusmn;0.22,重度组为3.26plusmn;0.09与对照组的2.48plusmn;0.94相比较同样具有统计学意义Plt;0.05。结论：阿尔茨海默病与胰岛素抵抗及胰岛beta;细胞功能的相关性。 　　【关键词】 阿尔茨海默病 认知功能 胰岛素抵抗 胰岛素抵抗指数 胰岛beta;细胞功能 胰岛beta;细胞功能指数 　　【中图分类号】R45 【文献标识码】A 【文章编号】2095-1752（2014）20-0037-02 　　【Abstract】Objective : To investigate Alzheimers disease (Alzheimers disease, AD) and insulin resistance and pancreatic beta; -cell function correlated to improve therapy for patients with AD . Methods : 60 patients with AD as experimentally observed object, and in strict accordance with GDS patients were divided into mild, moderate and severe levels of three different patients , age 40 re-election as a comparison of normal people . Then chemiluminescence and glucose oxidase on the two populations to detect glucose and insulin levels . And calculate their insulin resistance index . Results: Compared with normal subjects, AD patients under insulin fasting state are rising , and the insulin resistance index were higher than the normal group . The average fasting insulin levels in AD patients was 98.16 plusmn; 10.28pmol / L, where mild group 108.47 plusmn; 10.39pmol / L; moderate group was 94.03 plusmn; 6.06pmol / L; severe group was 93.68 plusmn; 6.38pmol / L in the control group, the average content of only 68.89 plusmn; difference 13.89pmol / L compared with the results of the two groups was significant that P lt;0.05. HOMA2-IR: LOAD obse