探讨骨髓活检组织病理在骨髓增生异常综合征诊断中的价值.docVIP

精品论文 参考文献 探讨骨髓活检组织病理在骨髓增生异常综合征诊断中的价值 大庆油田总医院 163000 【摘 要】 目的 研究分析骨髓活检组织病理在骨髓增生异常综合征诊断中的价值。方法 此次研究的对象是选择52例骨髓增生异常综合征患者，并作为观察组，52例健康体检者作为对照组。将其临床资料进行回顾性分析，并均行骨髓活检和骨髓涂片，对比两组单位面积内的肥大细胞和巨核细胞计数，分析观察组细胞发育形态、骨髓增生程度。结果 观察组单位面积内肥大细胞和巨核细胞计数（21.84plusmn;0.52）、（17.52plusmn;0.69）个/mm2均高于对照组（Plt;0.05）。观察组细胞发育形态异常率为100.00%。24例骨髓涂片和骨髓活检增生程度相符；21例骨髓活检增生程度高于骨髓涂片；7例骨髓涂片高于骨髓活检。结论 骨髓活检和骨髓涂片联合检查有利于骨髓增生异常综合征的诊断，值得广泛应用于临床。 【关键词】 骨髓活检；组织病理；骨髓增生异常综合征 [Abstract] Objective To study the value of bone marrow biopsy in the diagnosis of bone marrow hyperplasia syndrome.Methods the study subjects were selected from 52 cases of patients with bone marrow hyperplasia，and as the observation group，52 cases of healthy persons as the control group.The retrospective analysis of the clinical data，and underwent bone marrow biopsy and bone marrow smear，compared two groups of units in the area of mast cell and megakaryocyte counts，analysis of the observation group cell morphology，bone marrow hyperplasia degree.Results in the observation group，the number of mast cells and giant cell counts（21.84 + 0.52）and（17.52 + 0.69）/mm2 were higher than those in the control group（Plt;0.05）.The abnormal rate of cell growth was 100% in the observation group.24 cases of bone marrow smear and bone marrow biopsy were consistent with the degree of hyperplasia，21 cases of bone marrow biopsy were higher than the degree of bone marrow smear; 7 cases of bone marrow smear was higher than the bone marrow biopsy.Conclusion the combination of bone marrow biopsy and bone marrow smear examination is beneficial to the diagnosis of the syndrome of the proliferation of the bone marrow，and it is worth to be widely used in clinic. [Key words] bone marrow biopsy; histopathology; bone marrow hyperplasia syndrome 无效造血合并一种或多种骨髓病态发育性改变的克隆性造血干细胞肿瘤即为骨髓增生异常综合征[1]。主要表现为病态发育的血细胞形态学和细胞遗传学改变及一种或多种血细胞减少的异质性疾病。骨髓活检和骨髓涂片细胞检查是诊断骨髓增生异常综合征的“金标准” [2]。本文探讨骨髓活检组织病理对骨髓增生异常综合征的诊断价值，报告如下。 1 资料与方法 1.1 一般资料