腹腔镜手术治疗重症急性胰腺炎及对TNF-α、IL-6和sIL-2R水平的影响.docVIP

腹腔镜手术治疗重症急性胰腺炎及对TNF-α、IL-6和sIL-2R水平的影响 王军锋 李娜 罗卿 核工业四一七医院检验科 西安交通大学第一附属医院检验科 核工业四一七医院外一科 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 探讨重症急性胰腺炎 (SAP) 腹腔镜手术治疗的临床疗效及对肿瘤坏死因子-α (TNF-α) 、白细胞介素-6 (IL-6) 和可溶性白细胞介素-2受体 (s IL-2R) 水平的影响。方法 收集到西安交通大学第一附属医院接受外科手术治疗的SAP患者92例作为本次研究对象, 将其分为开腹组46例, 给予传统开腹手术治疗, 腹腔镜组46例, 实施腹腔镜手术治疗, 对比两组相关指标差异及对TNF-α、IL-6、s IL-2R水平的影响。结果 腹腔镜组手术时间 (82.21±14.56) min、术中出血量 (172.23±23.31) ml、手术总费用 (21 512.46±121.35) 元及住院天数 (16.81±0.58) d均少于开腹组;腹腔镜组治愈率93.48% (43/46) 明显高于开腹组76.08% (35/46) ;其并发症率10.86% (5/46) , 死亡率2.17% (1/46) 均明显低于开腹组;术后腹腔镜组TNF-α (24.70±6.90) ng/L、IL-6 (18.31±8.91) ng/L及s IL-2R (98.60±8.91) pmol/L明显低于开腹组, 以上数据组间对比差异有统计学意义 (P0.05) 。结论 采用腹腔镜手术治疗SAP, 其疗效显著, 可有效降低并发症率与死亡率, 且提高治愈率, 值得推广应用。 关键词： 重症急性胰腺炎; 腹腔镜手术; 肿瘤坏死因子-α (TNF-α) ; 白细胞介素-6 (IL-6) ; 可溶性白细胞介素-2受体 (sIL-2R) ; 作者简介：李娜, E-mail;Tel收稿日期：2017-04-18 Impact of laparoscopic surgical intervention for severe acute pancreatitis on TNF alpha, IL-6 and sIL-2R Jun-feng Wang Na Li Qing Luo Department of Laboratory Medicine, the 417th Hospital of Nuclear Industry; Department of Laboratory Medicine, the First Affiliated Hospital of Xian Jiaotong University; Department of General Surgery, the 417th Hospital of Nuclear Industry; Abstract： Objective To study the impact of laparoscopic surgical intervention for severe acute pancreatitis on TNF alpha, IL-6 and s IL-2 R. Methods Take 92 patients with SAP accepted laparoscopic surgical intervention as the research object, they were divided into laparotomy group (46 cases) : received traditional open surgery; laparoscopic group (46 cases) : received laparoscopic surgery intervention. Then compare the levels of TNF alpha, IL-6 and s IL-2 R between the two groups. Results The time of laparoscopy group was (82.21 ± 14.56) min, intraoperative blood loss was (172.23 ± 23.31) m L, total cost was (21 512.46 ± 121.35) yuan, which was less than laparotomy group; the cure rate of laparoscopic group