替加环素超说明书药物利用评价标准的建立与应用.docVIP

替加环素超说明书药物利用评价标准的建立与应用 杨雪婷 郑鹏程 曹玮 云南省第一人民医院药学部 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的:建立替加环素超说明书的药物利用评价 (drug use evaluation, DUE) 标准, 为临床合理用药提供依据。方法:替加环素超说明书DUE标准包括管理指标、用药指征、用药过程和用药结果 4个部分, 其中用药指征包括超适应证 (占主导) 、超剂量、超适应人群和超疗程用药。回顾性分析96例超说明书应用替加环素患者的临床资料, 对超说明书用药情况及DUE监测结果进行综合性评价。结果:我院替加环素超说明书用药率为69.57% (96/138) ;替加环素超说明书DUE标准评价结果显示, 对四环素类抗菌药物无过敏、每日至少测量体温2次的符合标准率均为100%, 符合标准率较低的为降钙素原监测、肝功能监测及药品不良反应监测等。结论:我院替加环素超说明书用药情况常见, 且存在一定问题, 应不断完善医院替加环素超说明书合理用药质量保证体系, 保证临床用药安全。。 关键词： 替加环素; 超说明书; 药物利用评价; 回顾性分析; 作者简介：杨雪婷 主管药师, 硕士。研究方向:临床药学。E-mail:374095634@ 作者简介：曹玮 副主任药师, 硕士。研究方向:医院药学。E-mail:591769489@ 收稿日期：2017-07-26 基金：云南省卫生计生委卫生计生政策研究课题 (No.2015YNP06) Establishment and Application of Drug Use Evaluation Criteria of Off-label Drug Use of Tigecycline YANG Xueting ZHENG Pengcheng CAO Wei Dept. of Pharmacy, the First Peoples Hospital of Yunnan Province; Abstract： OBJECTIVE: To establish the drug use evaluation ( DUE) criteria of off-label drug use of tigecycline, so as to provide basis for the rational drug use in clinic. METHODS: The DUE criteria of off-label drug use of tigecycline were respectively management indicators, medication indication, medication duration and medication results, among which the medication indication included off-indications ( leading role) , off-dosage, off-population and off-course of treatment. Retrospective analysis was conducted on clinical data of 96 cases of off-label drug use of tigecycline, and comprehensive evaluation was conducted on monitoring results of status of off-label drug use and DUE of off-label drug use of tigecycline. RESULTS: The off-label drug use rate of tigecycline was 69. 57% ( 96/138) . The DUE criteria of off-label drug use of tigecycline showed that qualified rate toward no allergy to tetracycline antibiotics and taking temperature at least twice a day was 100%; yet monitoring of PCT, liver function and adverse drug reactions had lower qualified rate. CONCLUSIONS: The p