疏肝运脾法对肥胖合并高血压的降压疗效及对胰岛素抵抗的影响Antihypertensive efficacy of Shugan Yunpi Decoction on obesity with hypertension and its effect on insulin resistance.pdfVIP

提 要 目的：评价疏肝运脾法对肥胖合并高血压的降压疗效及对胰岛素抵抗的影响，为 中医药治疗肥胖合并高血压提供一个思路。 方法：将 60 例肥胖合并高血压患者随机分为试验组，对照组各 30 例，对照组给 予二甲双胍治疗，而试验组给予疏肝运脾汤治疗，疗程为 2 个月，观察治疗前后各组 的临床症状，体重指数、血压、甘油三酯、胆固醇、低密度脂蛋白、高密度脂蛋白， 胰岛素抵抗、血尿常规、肝肾功的变化，比较其治疗前后及两组之间的疗效差异。 结果：试验组的症状改善总有效率为（93.33% ），显效率为（63.33% ），与对照 组相比有显著性差异（P0.05 ）；试验组体重指数、血压水平、甘油三酯、胆固醇、 低密度脂蛋白、高密度脂蛋白、胰岛素抵抗指数（HOMA-IR index ）与对照组比较， 有统计学意义(P0.05 ）。 结论：疏肝运脾汤治疗肥胖合并高血压不仅具有显著的疗效，而且具有充分的中 医理论基础和现代医学理论基础，是治疗肥胖合并高血压的一种有效的治疗方法，并 且具有改善胰岛素抵抗。 关键词 胰岛素抵抗；疏肝运脾；体重指数；肥胖；高血压 The Antihypertensive Effect and Influence of Insulin Resistance of shuganyunpi In Obesity and Hypertension Speciality：Internal Medicine of Traditional Chinese Medicine Author ：ZhengLi-hu Tutor ：Prof. Li Xiao Abstract Objective ：To evaluate the Antihypertensive effect and influence of Insulin resistance of shuganyunpi fa in Obesity-related hypertension and provide an idea of treatment of Obesity-related hypertension with traditional Chinese medicine. Methods ：60 patients of Obesity-related hypertension were divided into treatment group(n=30),control group (n=30). the treatment group were treated with shuganyunpiyang, the control group were treated with metformin, 2 months later, we will observe the changes of clinical symptom , Weight index ,Blood pressure, TG, TC, HDL-C,LDL-C, Insulin resistance, blood convention , uro convention, liver function ,renal function before and after treatment in each group and Difference in efficacy between the groups. Results: In the treatment group, the total effective rate of meliorating symptoms and the remarkable rate were respectively 93.33% and 63.33%,which were significantly better than those of the control group （P0.05 ）. Compared with contro