活血清肝煎剂预防慢性乙型肝炎肝硬化早癌转变效果观察.docVIP

精品论文 参考文献 活血清肝煎剂预防慢性乙型肝炎肝硬化早癌转变效果观察 张巍 苏国权 刘彦华 张照琪 戴二黑 邵明亮 　　[摘 要]目的 观察自拟活血清肝煎剂预防慢性乙型肝炎肝硬化患者发生早癌转变的效果。方法选取确诊为乙型肝炎肝硬化伴有不典型结节性增生（HDN）患者100例根据入院先后随机分为常规治疗组，中西医结合组。常规组、中西医结合组均按照慢性肝炎临床诊常规保肝治疗，给予保肝（复方甘草酸）、抗病毒（恩替卡韦）治疗。中西医结合组给予活血清肝煎剂及中药足浴配合常规治疗一疗程(4周)，与治疗前比较临床症状及实验室检查指标改善情况。结果 活血清肝煎剂改善慢性肝病患者临床症状，肿瘤相关的糖类抗原指标分别为（CA12-5 26.3plusmn;3.11，CA19-9 33.45plusmn;1.72，CEA6.74plusmn;0.66）明显降低，抑制甲胎蛋白AFP（12.10plusmn;1.50）及异质体的水平 （5.92plusmn;0.75）。结论活血清肝煎剂明显预防慢性肝病癌变具有作用，是理想的延缓病情进展、防癌中药制剂。 　　[关键词]慢性肝炎 肝癌 中药 　　The Effect of Huoxueqinggan Decoction in Prevention Patients with Chronic Hepatitis B Cirrhosis from Early Cancer 　　Zhang Wei, Su Guoquan, Liu Yanhua ,Zhang Zhaoqi, Dai Erhei, Shao Mingliang 　　Abstract: Objective To observe the effect of Huoxueqinggan decoction in prevention in patients with chronic hepatitis B cirrhosis from early cancer. Methods 100 cases with hepatitis B cirrhosis associated with atypical hyperplasia (HDN) were randomly divided into routine treatment group (48 cases) and TCM medicine group (52 cases). Both the conventional and medicine group were given routine uhepatoprotective (compound glycyrrhizic acid), antiviral (entecavir) treatment. The TCM medicine group was given Huoxueqinganyin decoction combined with routine therapy and traditional medicine foot bath treatment (4 weeks). The clinical symptoms and laboratory indicators were compared before and after the treatment. Results Huoxueqinganyin decoction can improve clinical symptoms in patients with chronic liver diseases. The tumor associated carbohydrate antigen index were decreased significantly (previous index: CA12-5 26.3 plusmn; 3.11, CA19-9 33.45 plusmn; 1.72, CEA6.74 plusmn; 0.66). Besides, the inhibition of alpha fetal protein AFP (12.10 plusmn; 1.50) and the heterogeneity level (5.92 plusmn; 0.75) were both restricted. Conclusion Huoxueqinganyin decoction can significantly prevent canceration of chronic liver disease with disease progression. It is the ideal anti-cancer traditional C