上海交大外科学16-外科学与免疫学.ppt

外科学与免疫学Surgery Immunology ;基本概念Basic Principles ;● 免疫: Immune: protect from pathogens ● 免疫性 Immunity: Capacity of defense infection ● 免疫应答 Immune response : response of recognition and elimination antigenicity foreign material ● 免疫学 Immunology: The science study on the structure function of the immune system Science of self-nonself discrimination;天然免疫与获得性免疫Adaptive and Innate immunity;Adaptive or Specific Immune response Highly specific for a particular pathogen ● Specific ● Muti-type ● Remember/ memory ● Transferable ;;Lymphoid Tissues;Cells of the Innate Immune System;Cells of the Adaptive Immune System;;;;Surface Molecules Expressed on DC;抗原递呈细胞的表面标志;T B 细胞表面标志的主要差别;Molecules of immune sys;TCR;MHC;Antigen presentation抗原递呈;Antigen Processing and Presentation抗原加工与递呈;Two pathways of protein Ag processing presentation蛋白质抗原加工递呈的两类途径;;Main molecules associated with T cell activation;;;T cell Activation;;;Cell-mediated cytotoxicity;Mechanisms of cytotoxicity;Immune Response;Antibody;T cell;NK and Mφ;Cytokine;Immunity to viruses病毒免疫;;Innate immune response to viruses天然免疫;Adaptive immune response获得性免疫应答;Adaptive immune response获得性免疫应答;;Tumor Immunology;Immune surveillance免疫监视;Immune surveillance免疫监视的证据;Cause of common tumour viruses involved immunodeficiency types Inherited lymphoma EBV immunodeficiency lymphoma EBV cervical cancer papilloma viruses immunosuppression skin cancer probably for organ transplants papilloma or due to AIDS viruses liver cancer hepatitis B and C viruses Kaposi’s human herpes sarcoma virus 8 malaria Burkitt’s EBV lymphoma autoimmunity lymphoma EBV;Tumour Organism Adult T-cell leukaemia Human T leukaemia virus I (HTLV I) Burkitt’s lymphoma and EBV Lymphoma in immunosuppression Cervical cancer Human papilloma viruses (HPV 16 and 18 and others) Liver cancer Hepatitis B and C Nasopharyngeal cancer EBV