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N乙酰氨基葡萄糖对骨折修复中成骨细胞活性和骨形态发生蛋白的影响
中国临床康复 第 10巷第5期 2006-02-10出版
158 ChineseJournalofClinicalRehabilitation,February102006Vol.10No.5
·BASICRESEARCH
EffectofN-acetylglucosamineonosteoblasticactivityandexpression of
bonemorphogeneticproteininfracturehealing
CuiYi-qun,ShenRuo-wu
DepartmentofHumanAnatomy,MedicalCollegeofQingdaoUniversity, CuiYQ,ShenRW.EffectofN-acetylglucosamineonosteoblasticactivityandex-
Qingdao266021,ShandongProvince,China pressionofbonemorphogeneticproteininfracturehealing.ZhongguoGinchuang
CuiYi-qun*,Master,Associateprofessor,DepartmentofHumanAnatomy, Kangfu2006;10151:158-601Chinal Il
MedicalCollegeofQingdaoUniversity,Qingdao 266021,Shandong
Province,China cuiyiqun@ INTRODUCTION
Received:2005-06-14 Accepted:2005-10-20 (04-25-12-8503/ZS) Astheonlypositiveionhigh-molecularpolymeravailableat
present, chitinispreparedfromthepositivelychargedglu-
Abstract
cosamineextractedfromtheshellsoftheshellfishspecieswith
BACKGROUND:Chitinanditsderivativespossessmanybiologicalac-
solubilityinacidsolutionandabsorbability.Ithasstrongaffinity
tivitiessuchasimmunemodulationandpromotingwoundhealingand
hemostasis.Asoneofthederivativesofchitin,theeffectofN-acetylglu- tocellswithsuchactivitiesinvivoasantibiosis,enhancingim-
cosamineonfracturehealinghasnotyetbeenacknowledged. munity,retainingmoisture,adsorbingandeliminatingdeposited
OBJECTIVE:Toobservethechangesinosteoblasticactivityandtheex- h
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