超临界流体药物微粒制备技术专辑-超临界流体协会.PDFVIP

臨流粒  李      臨流奈度粒 年來讀   (1) 臨supercritical assisted-atomization, SAA hydroxypropyl methylcellulose, HPMC 粒 ampicillin, AMP 行粒 (2) 臨supercritical antisolvent precipitation 臨rapid expansion from supercritical to aqueous solution, RESAS 臨度indomethacin (IMC) 粒 (3) 利臨cocrystallization with supercritical solvent, CSS 臨supercritical anti-solvent, SAS atomization and anti-solvent, AAS 類 indomethacin IMC 糖saccharin, SAC (4) 臨流奈 粒 (5) molecular dynamics, MD 臨rapid expansion supercritical solution, RESS 粒 率 粒             讀 1                 Reverchon, E.; Lamberti, G.; Antonacci, A., Supercritical fluid assisted production of HPMC composite microparticles, Journal of Supercritical Fluids, 46, 185-196 (2008). 臨流利 臨supercritical assisted-atomization, SAA hydroxypropyl methylcellulose, HPMC 粒 ampicillin, AMP 行粒 粒 狀狀粒粒0.05-5.2 µm SAA 粒DSC SEM EDX UV-vis 行HPMC AMP 不 量Z = HPMC/AMP 兩狀 行HPMC 狀率 72 hr 97 % AMP 8 hr 100 % AMP swelling control AMP HPMC erosion Reverchon, E.; Antonacci, A., Drug–polymer microparticles produced by supercritical assisted atomization, Biotechnology Bioengineering, 97, 6, 1626-1637, 2007 chitosan/AMP chitosan relaxation 狀離 狀離   讀 2                                      Tozuka, Y.; Miyazaki, Y.; Takeuchi, H., A combinational supercritical CO system 2 for nanoparticle preparation of indomethacin , International Journal of Pharmaceutics, 386, 243-248 (2010). 臨supercritical antisolvent precipitation 臨rapid expansion from supercritical to aqueous solution, RESAS scCO 類indomethacin, IMC