SCI写作讲义.ppt

医学文献的特点;Publish or perish!;;;;Essentials in Writing;FUNCTIONS of the Introduction;STORY LINE;Introduction;It is known that several general anesthetics, including barbiturates, depress the bronchomotor response to vagus never stimulation [1,7,9]. However, the site of this depression has not been determined. To determine which site in the vagal motor pathway to the bronchioles is most sensitive to depression by barbiturates, we did experiments in isolated rings of ferret trachea in which we stimulated this pathway at four different sites before and after exposure to bartiturates.;Novelty;Diagnostic study;Clinical studies;Problem-oriented;Just case series ?;;;;How to write discussion from results?;How to write discussion from results?;;;;Essential Biomedical Journals;科研伦理与学术不端行为;第一部分 研究伦理;研究伦理——国内外规范性文件;涉及人的生物医学研究必须遵循的基本原则： “尊重”——自主权、知情权、隐私权 “有利”——受试者、家人、社会 “无伤”——伤害最小化（身体、心理、精神、 经济、社会），及时（中）终止 “公正”——公平地选取，标准的纳入和排除;涉及人的生物医学研究如何体现四项原则？ 受试者知情同意书(Written Informed Consent) 试验设计方案(Study Protocol)经伦理委员会审核批准(Ethics Approval) 前瞻性干预性临床试验在世界卫生组织国际临床试验注册平台上注册(Clinical trial registration);临床实验 Materials and Methods: Written informed consent was obtained from the subjects, and the study was conducted according to the Declaration of Helsinki. The protocol was reviewed and approved by the local ethics committee (Comité de Protection des Personnes, Sud-Est 1, France) and registered at (reference: NC. ; 十九世纪以来，随着以动物为主要研究对象的实验医学的问世和推广，为动物福利立法已经成为国际社会的共识。 《实验动物管理条例?》 《实验动物质量管理办法?》 《实验动物许可证管理办法(试行)?》 《关于善待实验动物的指导性意见?》; 动物实验伦理的基本原则是禁止虐待实验动物，即保证受试动物的基本生活权利。 《人道主义实验技术原理》提出“3R”原则： “替代”(Replacement) “减少”(Reduction) “优化”(Refinement) ??—英国动物学家罗素、微生物学家伯奇，1959年; 动物实验应符合研究所在地的，全国性实验动物操作规范，并取得伦理许可。 Guide for the Care and Use of Laboratory Animals b) Ethical Committee for Animal Use of XXX University ;动物实验 Materials and Methods: The animal experiments were performed according to the Guide for the Care and Use of Laboratory Animals; the study protocol was approved by the Instit