基于介电特性的人体恶性胃组织支持向量机辅助诊断方法.PDFVIP

J South Med Univ, 2017, 37(12): 1637-1642 doi 10.3969/j.issn. 1673-4254.2017.12.13 ·1637 · 基础研究 基于介基于介电特性的电特性的人体恶性胃组织支持向量机辅助诊断方法人体恶性胃组织支持向量机辅助诊断方法 1 2 1 张 洒 ，厉 周 ，辛学刚 1 2 南方医科大学生物医学工程学院，广东 广州 510515 ；南方医科大学珠江医院普外科，广东 广州 510280 摘要：目的基于正常和恶性胃组织介电特性值的差异，运用支持向量机（SVM）对介电特性进行自动鉴别。方法 用开端同轴探 头法测量正常和恶性胃组织在42.58~500 MHz 频率范围内的介电特性，并对测得的介电特性数据进行Cole-Cole模型拟合。接 收机操作特性（ROC）曲线分析法被用来对各频率点下介电常数、电导率和Cole-Cole 拟合参数的鉴别能力进行评估。SVM被 用来对正常和恶性胃组织进行鉴别，鉴别正确率由k 折交叉验证进行计算。结果 在测量频率范围内，5个低端频率点下介电常 数的ROC 曲线下面积达到0.8 以上。这5 个频率下介电常数的组合作为特征值与SVM结合取得了最高鉴别正确率84.38% ， MATLAB运行时间为3.40 s。结论 本文提出的基于介电特性的恶性人体胃组织支持向量机辅助诊断方法具有可行性。 关键词：介电特性；恶性胃组织；鉴别；ROC 曲线；支持向量机 Support vector machine-assisted diagnosis of human malignant gastric tissues based on dielectric properties 1 2 1 ZHANG Sa , LI Zhou , XIN Xuegang 1School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China; 2Department of General Surgery, Zhujiang Hos- pital, SouthernMedical University, Guangzhou 510280, China Abstract: Objective To achieve differential diagnosis of normal and malignant gastric tissues based on discrepancies in their dielectric properties using support vector machine. Methods The dielectric properties of normal and malignant gastric tissues at the frequency ranging from 42.58 to 500 MHz were measured by coaxial probe method, and the Cole-Cole model was used to fit the measured data. Receiver-operating characteristic (ROC) curve analysis was used to evaluate the discrimination capability with respect to permittivity, conductivity, and Cole-Cole fitting parameters. Support vector machine was used for discriminating normal and malignant gastric tissues, and the discrimination accuracy was calculated using k-fold cross-validation. Results The area under the ROC curve was above 0.8 for