烟台458例儿童乙肝表面抗体调查分析.docVIP

精品论文 参考文献 烟台458例儿童乙肝表面抗体调查分析 吴丽莉 胡雪梅 (滨州医学院 256600) 　　【摘要】目的：跟踪调查458名按正常免疫接种程序完成乙肝疫苗接种儿童乙肝抗体的产生情况,为预防乙肝提供参考资料。方法：对458名儿童血清采用酶联免疫分析(ELISA)方法检测乙肝抗体的结果进行回顾性统计分析。结果：8月龄时93.6％的儿童乙肝抗体为阳性，而到4周岁时乙肝抗体阳性率仅为19.2％,差异明显。单独接种深圳康泰疫苗的8月龄儿童乙肝抗体阳性率90.9％，4周岁乙肝抗体阳性率12.1％，混合接种8月龄儿童乙肝抗体阳性率91.4％，4周岁乙肝抗体阳性率16.5％，差异无统计学意义。结论：4岁儿童乙肝抗体阳性率较8月龄儿童明显下降，且混合接种不影响乙肝抗体产生效果，及时对抗体阴性儿童及时进行疫苗补种对防治乙肝具有重要意义。 　　【关键词】儿童 乙肝表面抗体 　　【中图分类号】R725.1 【文献标识码】A 【文章编号】1672-5085（2014）07-0075-02 　　Investigation of surface antibody Yantai 458 cases of children with hepatitis B 　　Wu Lili 1 Xue-Mei Hu 2 　　【Abstract】Objective: tracked 458 normal immunization program for children to complete the hepatitis B vaccination of hepatitis B antibodies, the reference data for the prevention of hepatitis. Methods: 458 children in serum using an enzyme-linked immunoassay (ELISA) to detect hepatitis B antibody results were retrospectively analyzed. Results: 93.6% of 8-month-old children with hepatitis B antibody positive, and 4 years of age when HBV antibody positive rate was 19.2%, the difference is obvious. Shenzhen Kangtai vaccine inoculation alone 8-month-old children with hepatitis B antibody positive rate of 90.9%, 4 years of hepatitis B antibody positive rate of 12.1%, 8-month-old child mixed hepatitis B vaccination antibody positive rate was 91.4%, 4 years of hepatitis B antibody positive rate of 16.5%, the difference was not statistically significant. Conclusions: HBV antibody positive rate 4-year-olds decreased significantly compared with 8-month-old child, and the mix of hepatitis B vaccination does not affect antibody production results in a timely manner to the antibody-negative children in a timely manner to replant the prevention of hepatitis B vaccine is important. 　　【Key words】Children hepatitis B surface antibody 　　乙型肝炎是由乙型肝炎病毒感染所引起的一种传染病，接种乙肝疫苗是一种最常用的预防手段。 为了解正常接种乙肝疫苗儿童乙肝抗体产生情况，为乙肝防治提供资料，本文对458名正常接种乙肝疫苗儿童采用酶联免疫法（ELISA），检测8月龄时和4周岁时血清乙肝表面抗体情况，并对结果进行回顾性统计分析。现报告