瘦素瘦素受体相关信号通路与肿瘤的研究进展.docVIP

精品论文 参考文献 瘦素瘦素受体相关信号通路与肿瘤的研究进展 1.南华大学附属郴州医院 湖南郴州 423000；2.南华大学附属南华医院 湖南衡阳 421000 摘要：流行病学调查显示肥胖是多种肿瘤的形成的危险因素。肥胖，被认为是一种轻微的炎症反应过程，其特征性表现是脂肪组织高水平分泌与肿瘤发生发展相关的细胞因子如：瘦素。瘦素是一种主要由白色脂肪合成、分泌的多肽类激素，在肥胖相关肿瘤中有促炎症反应、促血管生成、扩散、迁移、凋亡等的作用。研究表明瘦素受体在多种类型肿瘤中过度表达，且与肿瘤血管生成、肿瘤细胞凋亡、炎症反应、促有丝分裂活性具有相关性。瘦素/瘦素受体主要是通过经典的信号通路Janus激酶2/信号转导和转录激活因子3（Janus Kinas2/Signal Transducers and Activators of Transcription 3，JAK2/STAT3），促分裂素原活化蛋白激酶/细胞外调节蛋白激酶1/2（Mitogen activated protein kinase/ Extracellular regulated kinase 1 and 2，MAPK/ERK1/2），磷脂酰肌醇3激酶/蛋白激酶B（Phosphoinositide 3-kinase/ Protein kinase B，PI3K/AKT）和非经典信号通路维持机体食物摄取、能量平衡、脂肪代谢、免疫反应、内分泌系统的稳定，且能在肿瘤发生、发展过程中起作用。但是，瘦素促进肿瘤发生发展的的机制善不完全清楚。本文从瘦素通过经典的JAK2/STAT3，MAPK/ERK1/2，PI3K/AKT对肿瘤影响的研究做一综述。 关键词：瘦素；瘦素受体；JAK2/STAT3信号通路；MAPK/ERK1/2信号通路；PI3K/AKT信号通路；肿瘤 Leptin/Leptin Receptor Signaling Pathway research progress of effects on Tumors Abstact Epidemiologic studies have suggested obesity may as a high risk factor in various cancers.Obesity is redarded as a mild inflammatory condition，its characteristic is high levels of cytokines from adipose tissue secretory related to cancers development such as：Leptin.Leptin，mainly secreted by adipose tissue，peptide hormone secretion，are involved in thses biological processes pro-inflammatory，pro-angiogenic，proliferation，migration，anti-apoptosis in obesity-related cancers.Supporting evidence overexpression of Leptin receptor（Ob-R）in various cancer，and involved in angiogenic，apoptosis，inflammatory responses，mitogenic activity.Leptin/Leptin Receptor is responsible for several canonical signaling pathways signal transduction through the activation of Janus-activated kinase 2（JAK2）/signal transducers and activatiors of transcription 3（STAT3），the mitogen-acctivated protein kinase（MAPK）/extracellular signal-regulated kinase（ERK），phosphatidylinositol 3-kinase（PI3K）/protein kinase B（AKT）and non-canonical signaling pathways.Leptin-induced signals is essential to its biological effects on food intake，energy balance，adiposity，immun