盐酸安非他酮缓释片治疗30例抑郁症疗效及安全性分析.docVIP

精品论文 参考文献 盐酸安非他酮缓释片治疗30例抑郁症疗效及安全性分析 吴逢春 宁玉萍（通讯作者）（广州医学院附属广州市精神病医院 广东广州 510370） 【中图分类号】R971.43【文献标识码】A【文章编号】1672-5085（2012）15-0099-02 【摘要】目的 探讨盐酸安非他酮缓释片治疗抑郁症的临床效果及其安全性。方法 选取2009年4月-2010年1月我院接收的60例抑郁症患者，将其随机分为研究组和对照组，每组各30例，研究组患者口服盐酸安非他酮缓释片，而对照组患者口服氟西汀，治疗结束后，观察两组患者临床治疗效果、汉密尔顿抑郁量表评分变化以及不良反应发生情况等。结果 两组汉密尔顿抑郁量表评分相比于治疗前均明显减少，但两组对比差异不具有统计学意义(P＞0．05)。治疗结束后，研究组治疗有效率为83.33%，对照组治疗有效率为80%，差异无统计学意义(P>0.05).两组各有2例患者出现轻中度不良反应，不影响继续用药。结论 作为一种新型治疗抑郁症药物，盐酸安非他酮缓释片具有较好的治疗效果和安全性，值得进行临床推广和进一步研究。 【关键词】盐酸安非他酮 氟西汀 抑郁症 疗效 安全性 【Abstract】 Objective to explore efficacy and security of bupropion SR tablet in the treatment of depression. Methods select April 2009-January 2010 of our hospital receiving 60 cases depression patients, it will be divided into research group and control group, each group of each 30 cases, the research patients oral bupropion SR tablet, and the control patients oral fluoxetine, after treatment, the two groups were observed the clinical treatment effect, Hamilton depression rating scale change and adverse reaction. Results two groups of Hamilton depression rating scale than before treatment were significantly reduced, but the two groups of comparative differences were not significant (P > 0.05). After treatment, the research group treatment efficiency was 83.33%, the control group treatment efficiency was 80%, the difference was not statistically significant (P > 0.05). The two groups each have two patients appear mild-to-moderate adverse reaction, do not affect a stay on the drug. Conclusion as a new drug for the treatment of depression, bupropion SR tablet has good therapeutic effect and safety, it is worth for clinical promotion and further research. 【Key words】bupropion SR tablet fluoxetine Depression Efficacy Security 盐酸安非他酮〔bupropion〕是一种新型抗抑郁药物，临床上又称布普品，属氨基酮类化合物。目前其主要用于治疗抑郁症以及辅助治疗戒烟，其对耐受性较好，且对性功能影响较小，相比于三环类抗抑郁药，其对抗胆碱能和心血管的副作用明显减少[1]。其药理作用机制主要为抑制去甲肾上腺素以及多巴胺的双重递质再摄取，增强去甲肾上腺素能以及多巴胺能的功能，从而发挥抗抑郁作用[2]。其口服后吸收较好,在肝脏内代谢主要代谢产物为羟基安非他酮以及氢化安非他酮,具