盐酸帕洛诺司琼、昂丹司琼预防儿童髓外白血病化疗恶心、呕吐的临床研究.docVIP

精品论文 参考文献 盐酸帕洛诺司琼、昂丹司琼预防儿童髓外白血病化疗恶心、呕吐的临床研究 郭林梅 王君霞 　　兰州军区兰州总医院儿科 730050 　　摘要：目的 观察两种止吐药预防儿童髓外白血病化疗引起恶心、呕吐的临床疗效和不良反应。方法：将125例急性淋巴细胞白血病患儿随机分为2组，帕洛诺司琼组65例、昂丹司琼组60例，均采用大剂量甲氨碟呤-四氢叶酸钙（HDMTX-CF）化疗方案治疗，并分别给予帕洛诺司琼、昂丹司琼，观察2种药物预防呕吐的效果。结果：急性期防治呕吐的有效率帕洛诺司琼组为96.92%，昂丹司琼组为95%；延迟期有效率分别为89.23%、75%，帕洛诺司琼组与昂丹司琼组比较，差异有统计学意义（Plt;0.05）。2种止吐药的不良反应均为便秘、腹泻、头晕，且反应轻微。结论：盐酸帕洛诺司琼效果明显优于昂丹司琼，帕洛诺司琼预防儿童髓外白血病化疗所致恶心、呕吐效??较昂丹司琼更优，安全性相似，且临床应用更方便。 　　关键词：帕洛诺司琼；昂丹司琼；儿童髓外白血病；化疗；呕吐 　　Abstract：Objective To compare the effect and adverse reaction of palonosetron and ondansetron in prevent of nausea and vomiting caused by chemotherapy of children extramedullary leukemia .Methods 125 cases of patients with ALL were randomly divided into palonosetron group and ondansetron group，palonosetron group of 65 cases and ondansetron group of 60 cases，all were treated by chemotherapy of high dose methotrexate ndash;calium folinate drug（HDMTX-CF）and were given with palonosetron and ondansetron to prevent nausea，vomiting response；the nausea，vomiting control effect and adverse reactions of the two groups were observed. Two kinds of anti-nausea drug adverse reactions were constipation，diarrhea，dizziness，slight.Results The effective control rate of acute period nausea and vomiting in palonosetron group、ondansetron group，was 96.92%，95%；The effective control rate of delay period vomiting in palonosetron group，ondansetron group was 89.2%，75%，respectively，there was significant difference of palonosetron group compared with ondansetron group（Plt;0.05）. Conclusion The effect of palonosetron prevention malignant，vomiting caused by chemotherapy is better than that of ondansetron，the safety of two groups is similar and clinical use is convenient. 　　Keywords：palonosetron；ondansetron；children extramedullary leukemia；chemotherapy；vomiting 　　急性淋巴细胞白血病（acute lymphoblastic leukemia，ALL）是儿童期最常见的恶性肿瘤，也是导致儿童死亡疾病中较为重要的病因，虽有效化疗方案的实施大大降低了患儿的死亡率，但由于大多数药物不能进入中枢神经系统、睾丸等髓外部位，如不积极预防，可发生髓外白血病（extramedullary leukemia EL），如：中枢神经系统白血病（CNSL）在3年化疗期间的发生率