盐酸戊乙奎醚对体外循环患者IL-6和IL-10的影响.docVIP

精品论文 参考文献 盐酸戊乙奎醚对体外循环患者IL-6和IL-10的影响 胡彦艳 黄爱兰 卢小玲 叶凤青 朱蔚琳 万福红 黄中华 　　（广西壮族自治区人民医院麻醉科 广西南宁 530021） 　　【摘要】目的：探讨盐酸戊乙奎醚对体外循环（CPB）后IL-6和IL-10的影响。方法：选择ASAⅡ～Ⅲ级择期CPB下行心脏瓣膜置换手术患者40例，随机分为两组（n＝20）：盐酸戊乙奎醚（P）组和对照(C)组。分别在麻醉诱导后CPB前5min，P组静注PHC 0.1mg/kg，C组静注等量生理盐水。两组分别于麻醉前（T0）、主动脉阻断5 min（T1）、CPB结束 (T2) 、术后48h（T3）和术后1W（T4）抽血ELISA法测定IL-6和IL-10的浓度。结果：与T0比较，两组在T1～T4两指标均升高；与C组比较，P组的IL-6在T1～T3时下降、IL-10在T1～T4升高（P＜0.05）。结论：盐酸戊乙奎醚可减轻CPB后的炎性反应，增强抗炎作用。 　　【关键词】盐酸戊乙奎醚 体外循环 炎性反应 白介素 　　【中图分类号】R96 【文献标识码】A 【文章编号】1672-5085（2014）12-0160-02 　　Effects of penehyclidine hydrochloride on IL-6 and IL-10 induced by cardiopulmonary bypass HU Yan-yan,HUANG Ai-lan,LU Xiao-ling,et al. Department ofAnesthesiology,the Peoplersquo;s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China 　　Corresponding author: HUANG Ai-lan,Email:suezong@163.com 　　【Abstract】 Objective To investigate the effects of penehyclidine hydrochloride on IL-6 and IL-10 induced by cardiopulmonary bypass (CPB) .Methods Forty patients undergoing valve replacement with CPB were randomly divided into two groups(n=20): group PHC and group C. Pnehyclidine hydrochloride 0.1mg/kg was injected intravenously before 5min CPB.Blood samples were collected for IL-6 and IL-10 before CPB (T0),after 5min aorta block(T1),CPB cease（T2）and 48h (T3)and 1w(T4) after the operation .Results The levels of IL-6 was significantly lower and IL-10 was significantly higher in group P at T1~T3 than those in group C(P＜0.05). Conclusion Penehyclidine hydrochloride could inhibit inflammatory response induced by cardiopulmonary bypass and may be helpful in preventing the systemic inflammatory response . 　　【Key words】penehyclidine hydrochloride cardiopulmonary bypass inflammatory response Interieuki 　　体外循环（Cardiopylmonary bypass,CPB）导致全身炎症反应综合症是术后一系列并发症的病理基础，起作用的炎症介质有多种，其中白介素-6（interleykin-6,IL-6）和白介素-10（IL-10）在促炎和抗炎反应具有重要的作用。盐酸戊乙奎醚是新型的抗胆碱药，本研究通过CPB中使用盐酸戊乙奎醚，观察其对IL-6和IL-10的影响。 　　1 资料和方法 　　1