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Age effects on diffusion tensor magnetic resonance imaging…
Human Brain Mapping 27:230–238(2006)
Age Effects on Diffusion Tensor Magnetic
Resonance Imaging Tractography Measures of
Frontal Cortex Connections in Schizophrenia
Derek K. Jones,1,2 Marco Catani,2,3 Carlo Pierpaoli, 1 Suzanne J.C. Reeves,2
Sukhwinder S. Shergill,4 Michael O’Sullivan,5 Pasha Golesworthy,6
Phillip McGuire,4 Mark A. Horsfield,7 Andrew Simmons,6
Steven C.R. Williams,6 and Robert J. Howard2*
1Section on Tissue Biophysics and Biomimetics, LIMB, NICHD, National Institutes of Health,
Bethesda, Maryland
2Old Age Psychiatry, Institute of Psychiatry, London, United Kingdom
3Institute of Gerontology and Geriatrics, University of Perugia, Italy
4Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, London,
United Kingdom
5Division of Clinical Neuroscience, St. George’s Hospital Medical School, London, United Kingdom
6Neuroimaging Research, Department of Neurology, Institute of Psychiatry, London,
United Kingdom
7Division of Medical Physics, Leicester Royal Infirmary, Leicester, United Kingdom
Abstract: Diffusion tensor magnetic resonance imaging (DT-MRI) has previously been used to investigate
white matter tracts in schizophrenia, with inconsistent results. The aim of the study was to use a novel
method for tract-specific measurem
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