注射用氯诺昔康与注射用头孢甲肟在氯化钠注射液中配伍稳定性研究.PDFVIP

现代药物与临床 Drugs Clinic 第 29 卷 第 10 期 2014 年 10 月 ·1169 · 注射用氯诺昔康与注射用头孢甲肟在氯化钠注射液中配伍稳定性研究 朱 军，熊 琳，陈富超，陈琴华，李 鹏* 湖北医药学院附属东风医院 药学部，湖北 十堰 442008 摘 要：目的 考察注射用氯诺昔康与头孢甲肟在 0.9%氯化钠注射液中的配伍稳定性，为临床合理用药提供理论依据。方 法 在室温条件下，采用 HPLC 法测定 8 h 内配伍溶液中氯诺昔康、头孢甲肟的变化，并观察和检测外观、pH 值变化，结 果 配伍溶液在 8 h 内氯诺昔康的质量分数未见明显变化，但头孢甲肟质量分数不断下降，8 h 后为 95.3% 。pH 值随时间变 化逐渐降低，溶液颜色随时间变化逐渐加深。结论 在室温条件下，注射用氯诺昔康与注射用头孢甲肟在 0.9%氯化钠注射 液中 2 h 内保持稳定，可配伍使用。 关键词：注射用氯诺昔康；注射用头孢甲肟；配伍；稳定性；高效液相色谱 中图分类号：R927.1 文献标志码：A 文章编号：1674 - 5515(2014)10 - 1169 - 04 DOI:10.7501/j.issn.1674-5515.2014.10.023 Compatible stability of Lornoxicam for injection and Cefmenoxime for injection in 0.9% sodium chloride injection ZHU Jun, XIONG Lin, CHEN Fu-chao, CHEN Qin-hua, LI Peng Department of Pharmacy, Dongfeng Hospital Affiliated with Hubei University of Medicine, Shiyan 442008, China Abstract: Objective To study the stability of compatibility of Lornoxicam for injection and Cefmenoxime for injection in 0.9% sodium chloride injection to supply the evidence for clinical rational administration. Methods HPLC method was carried out to study the content change of cefmenoxime and lornoxicam in 0.9% sodium chloride injection under the room temperature. The appearance of the solution was observed and its pH value was determined. Results No significant difference was found in the content of lornoxicam within 8 h, but the contents of cefmenoxime declined with 95.3% of the initial concentration during 8 h. The pH value decreased and the color gradually deepened as time went on. Conclusion The mixture of cefmenoxime with lornoxicam in 0.9% sodium chloride injection can be used under the room temperature, but must be injected within 2 h. Key words: Lornoxicam for injection; Cefmenoxime for injection; compatibility; stability; HPLC 氯诺昔康为新型非甾体抗炎药，具有很强的抗 诺昔康与盐酸头孢甲肟在 0.9%氯化钠注射液中的 炎、镇痛作用，其消除半衰期短（约 3