炎症反应课件.ppt

2、 IκBα 1、IKK β 3、NF-κB磷酸化 阻断策略 抑制IKK:NEMO 抑制IκBα:突变体或超级抑制剂 抑制蛋白酶体:ps341;MG132 对NF-κB调控：抑制其磷酸化；阻断其核定位及与DNA的结合;抑制表达 抗氧化剂 Anti-TNF Obstructing the Sepsis Cascade: Attack Multiple hubs….. Drug Companies will have to co-operate! Anti-NFkB COX-2抑制剂的抗癌作用 COX-2在多种类型的肿瘤中过度表达； 多种选择性和非选择性的COX抑制剂可计量依赖性地预防多种动物模型癌症的发生； 流行病学研究表明NSAID可预防癌症的发生 机制：抑制细胞凋亡，增加血管再生，促进浸润 Traditional Medicine/Natural Products and anti-inflammation Traditional Medicine/Natural Products Between 1981 and 2002, 48 of 65 drugs approved for cancer treatment were natural products, based on natural products, or mimicked natural products in one form or another. Several population based studies indicate that people in Southeast Asian countries have a much lower risk of developing colon, gastrointestinal, prostate, breast, and other cancers than do their Western counterparts. It is likely that dietary constituents (e.g., garlic, ginger, soybeans, curcumin, onion, tomatoes, cruciferous vegetables, chilies, and green tea) play an important role in protection from these cancers. These dietary agents are believed to suppress the transformative, hyperproliferative, and inflammatory processes that initiate carcinogenesis. Because of their pharmacological safety, these agents can be used alone or as adjuncts to current chemotherapeutic agents to enhance therapeutic effects and minimize chemotherapy-induced toxicity. Hence, the real key to drug discovery lies in the development of therapeutic agents that are safe, effective, and affordable. We did find several proteasome inhibitor from natural products. These products have both effects on anti-cancer and anti-inflammation. Traditional Medicine/Natural Products The three steps of invasion are part of a bigger series of steps that result in metastasis. How do we put these steps together to create metastasis? It starts with the tumor cell growing. It becomes angiogenic. It then goes through the three steps of invasion, getting into the bloodstream. It circulates around.