生物化学原理教学（杨荣武）Chapter3 Structure and function relationships of proteins.pptVIP

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生物化学原理教学（杨荣武）Chapter3 Structure and function relationships of proteins.ppt

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Outline Functions of proteins Structure and function relationships of proteins General principles of structure-function relationships of proteins Several important proteins: structure-function relationships Protein function prediction Moonlighting proteins are proteins that have secondary (hidden) functions in addition to their primary functions. Many glycolytic proteins have moonlighting activities. A special class of moonlighting proteins are trigger enzymes that control gene expression in addition to their enzymatic function. An example: Glyceraldehyde-3-phosphate dehydrogenase can double as uracil DNA glycosylase. Beta-sheets found in beta-keratin Three effects make Hb more suitable for transporting O2 Positive cooperativity: two different models can be employed to explain this effect. Bohr effect Allosteric effect Hemoglobins Moving Around (To the tune of Santa Claus is Coming to Town) Copyright ? 2006 Kevin Ahern Oh isnt it great What proteins can do Especially ones that bind to O2 Hemoglobins moving around Inside of the lungs It picks up the bait And changes itself from T to R state Hemoglobins moving around Hemoglobins Moving Around The proto-porphyrin system Its iron makes such a scene Arising when an O2 binds Pulling up on histidine The binding occurs Cooperatively Thanks to changes qua-ter-nar-y Hemoglobins moving around Hemoglobins Moving Around It exits the lungs Engorged with O2 In search of a working body tissue Hemoglobins moving around The proton concentration Is high and has a role Between the alpha betas It finds imidazole Hemoglobins Moving Around To empty their loads The globins decree We need to bind 2,3BPG Hemoglobins moving around Hemoglobins Moving Around The stage is thus set For grabbing a few Cellular dumps of CO2 Hemoglobins moving around And then inside the lungs it Discovers ox-y-gen And dumps the CO2 off To start all over again So see how this works You better expect To have to describe the Bohr effect Hemoglobins moving around P