麻醉与器官保护PPT.ppt

;;Are the effects reversible - e.g.brain?这些影响可逆转吗 – 例如：脑？;Recovery differences-other organs恢复的差别 – 其他器官;Range of recovery恢复的范围;Do you practice anaesthesia with the firm belief, that when you switch off the anaesthetic, that the effects are fully reversible and that no harm is done to the patients?实施麻醉时您是否坚信在停药后麻醉药物的影响是否可以完全逆转而对病人没有伤害？;If you said yes… then why do we get………如果你的回答是“YES”，那么为什么我们还会遇到……..;What we do know我们所知的：;What we don’t know- what is the trigger for harm我们不知道的 – 导致伤害的诱因是什么？;Are all anaesthetics all equal?所有的麻醉药都一样吗？;We should not assume that all anaesthetics are equal, nor should we assume that all drugs from the same class are the same既不能假设所有的麻醉药是一样的，也不应该假设同类药物中所???的药是相同的;Example - effect on contractility举例 – 对心肌收缩力的影响;Example- effect on MAP举例 – 对平均动脉压的影响;Concept of organ protection器官保护的概念;;Organ protection器官保护;Organ protection器官保护; Mechanisms机制;Receptors受体;Organ Protection - what we do know器官保护 – 我们知道什么;Cardiac protection - fact or fiction?心脏保护 – 事实还是神话？;De Hert studies suggestive of similar effect between sevoflurane and desfluraneDe Hert的研究提示地氟烷和七氟烷具有相似的效果;Data from my lab (Dr David Andrews PhD student)本实验室数据; Methods方法; Methods方法; Animal data: Infarct / area at risk动物数据：梗死/受累区域;Results area at risk发生缺血危险的区域;Infarct size / Area of risk梗死面积/受累范围;Take home message提示;Other organs (mainly animal evidence)其他器官（主要是动物试验验证）;Combinations - propofol + volatile?联合 – 丙泊酚+吸入麻醉药？;Combination: consequences during IR联合用药：在IR的后果;What do I do我的做法;Conclusions结论