衰老期下丘脑-垂体-肾上腺皮质-胸腺轴的调控变化.doc

衰老期下丘脑-垂体-肾上腺皮质-胸腺轴的调控变化 国外医学?老年医学分册20o3年7月第24卷第4期 predictspatialleafingimpairmentinagedrats.JNe~osci, 2O0o;20(17):6587～6593 7Ga~leyAH,Siegd,KordowerJHela/.Circuit—specific alterationsofN—methyl——D——aspartatereceptorsubnit1in thedendategymsofagedmonkeys.ProcNatlAcadSciUSA. 1996;93(7):3121~3125 8AdamsMM,Smith11),MogaDela/.~pwr-amwa dependentlearningabiUitycorrelateswithN——methyl——D—— aslxmate(NMDA)receptorlevelsinCA3neul’oi~ofyoung andagedrats.JCompNeurol,2001;432(2):230--243 9TsienJg,HuertaPT,TonegawaSela/.1[1essentialmleof hip~palCA1NMDA plasticityinspatialm~l’g)l-y. 1338 receptor——amp;~dentsynaptic Cell,1996:87(7):1327～ 10ClaytonDA,BrowningMD.Deficitsinthe既ofthe 2Bsubunitinthehip~pusofagedFisher344rats. N~mbblAging,2001;22(1):165～168 11TangYP,ShimizuE,DubeGRela/.Geneticenhanoe~,nent oflearningandm~TIol”yinmice.Nature.1999;401:63～ 69 12ClaytonDA,MeschesMH,AlvarezEeta/.Ahip~pal NR2BdeficitcarImimicage—relatedch~’oqgesinlong—term potentiationandspatiallearningintheF~cher344rat.J Neurosci,2002;22(9):3628～3637 13Sherwin1313.Oestrogenandeogintivefunctionthrougheutthe fen~alelifespan.NovartisFotatclSymp,2O0o;230:188～ 196 14AdamsMM,FinkSE,ShahRAela/.Estrogenandaging effectthesubcelluardistributionofestrogenreceptor—alphain thehip~pusoffm~alerats.JNeurc~,2002~22 (13):3608～3614 15McEweenBS,AkamaK,AlesSela1.Trackingthe estrogenreceptorinne~rorl$im【pUcationsforestrogen— inducedsynapse.ProcNatlAcadSdUsA,2001;98(14): —— 159—— 7093～710o 16AdamsMM,ShahRA,JanssmWGHa/.Differential modesofhip~palphstidtyinresponsetoestrogenin youngandagedfemalsrats.ProcNatlAcadSciUSA,20o1: 98(14):8o71～8O76 17ShankarS,Tllyl口TJ,RobbimNela/.姚differentially altersformsoflong—teampotentiationinrathipl∞area CA1.JNeurophysio,1998;79(1):33_4～3_41 18FosterTc,Norris.Age—msoeiatedchaIin. dependentprocesses;relationtohlppcx~mmlmmaptical plasticity.Hip~us,1997;7(6):602~612 19NorrisaM,KorolDL,FosterTc.hl廿嘲sedsusceptibility toinductionoflong—telTndepressionandl0l1g—term potentiationreversalduringaging.JNeurosci,19