黄芪甲苷在心血管疾病中的作用.docVIP

黄芪甲苷在心血管疾病中的作用 ? l32?血管病学进展2011年1月第32卷第1期AdvCardiovascDis,January2011,Vo!.32,No.1 亡等方面达到保护心脏的作用,可作为糖尿病合并心Ill, 血管疾病患者的首选药物之一,为临床治疗开辟了新 的途径. [2] [3] [4] [5] 6 [7] [8j [9] [10] [参考文献] Noauthorslisted.Effectofintensiveblood.glucosecontm1withmetforminon complicationsinoverweightpatientwithtype2diabetes(UKPDS34).UKPro— spectiveDiabetesStudy(UKPDS)Group[J]Lancet,J998,352(9131):854— 865. EurichDT.MajumdarSR.McalisterFA,etalImprovedclinicaloutcomesas— soeiatedwithmeffonnininpatientswithdiabetesant{imartilmeJDiabetes Care.20o5,28(10):2345-2351. SolskovL,LofgrenB,KristiansenSB,ela1.Metforill;11indmescardioprotec tionagainstischaemia/repeffusioninjuryintheratheart24hoursafteradminis. tration[J].BasicClinPharmacolToxicol,2008,103(】):82?87 HardieDG,ScottJW,PanDA,eta1.Managementofcellularenergybythe AMP-activatedproteinkinasesystem[J]FEBSLett,2003,546(J):l13-120 HudsenER.PanDA.JamesJ,eta1.AnoveldomaininAMP—activatedprotein kinasecausesglycogenstoragebodiessimilartotlmseseeninheredita~cardiac arrhythmiasj.CurtBiol,2003,13(10j:861—866 PolekhinaG,GuptaA,Michel1BJ,etaiAMPKbetasubunittargetsmetal,olic stresssensingtoglycogen[JCurlBio1.2003,13(10):867—87l CheungPC,SaltIP,DaviesSP.eta1.CharacterizationofAMPactivatedpro teinkinasegammasubunitisoforillsandtheirroleinAMPbndiag『JBioci,em J,2000,346(3):659-669. HattoriY.SuzakiK,HattoriS,etalMettbrrninlnhibitscytokine—inducednu. clearfactorkappaBactivationviaAMP—Hcti,atedproteinkinaseactivationinvas. cularendothelialcellslJ].Hypertension,2006,47(6):1183-188. KudoN,BanAJ,BanRL,eta1.ffighratesotihttyacidoxidationduring reperfusionofischemicheartsareassociate(iwithadecreaseinnralonylCoA1ev elsduetoanincrensein5.AMP.aetivatedproteinkinaseinhibifionoface@一 CoAcarboxylase[J].JBiolChem,1995,270(29):17513—17520. MarsinAS.BertrandL.RiderMH.eta1.PJmsphorylationan(iactivationot hearlPFK_2bvAMPKhasaroleinthestimulationofglycolysis(1uringischae [12] 13] l4] [15j mia[J]CurtBiol,2000,10(20):1247—1255. KukidomeD,NishikawaT,SonodK,eta1.ActivationofAMP—activate