第十一章抗原提呈细胞与抗原提呈.pptVIP

第十一章 抗原提呈细胞与抗原的处理与提呈;T cells do not recognise native antigens;Cell surface peptides of Ag;基本内容;一、基本概念;二、抗原递呈细胞的种类; ;;;DC的特点及功能：;未成熟DC与成熟DC的区别：;2. 巨噬细胞（macrophage, MФ）;;;;;;3. B细胞;三、抗原加工和递呈的途径;（一）外源性抗原的加工递呈;1. 外源性抗原的摄取;2. 外源性抗原的加工;3. MHC Ⅱ类分子的生物合成和转运;Ii链的作用：;4. MHCⅡ类分子荷肽;MHCⅡ类分子荷肽过程：;5. 外源性抗原的递呈;Y;100;Proteases produce ~24 amino acid long peptides from antigens Drugs that raise the pH of endosomes inhibit antigen processing;Activation of Cathepsin B at low pH;Need to prevent newly synthesised, unfolded self proteins from binding to immature MHC ;Invariant chain structure;A peptide of the invar