基因,蛋白,免疫 课程4.doc

窗体顶端 Nature ? 2000 Nature Publishing Group Volume 406(6797)? ? ? ? ? ? ?17 August 2000? ? ? ? ? ? ?pp 747-752 Molecular portraits of human breast tumours [Letters to Nature] Perou, Charles M.*?; S?rlie, Therese??; Eisen, Michael B.*; van de Rijn, Matt§; Jeffrey, Stefanie S.[//]; Rees, Christian A.*; Pollack, Jonathan R.[curved stem paragraph sign ornament]; Ross, Douglas T.[curved stem paragraph sign ornament]; Johnsen, Hilde?; Akslen, Lars A.#; Fluge, ?ystein[white star]; Pergamenschikov, Alexander*; Williams, Cheryl*; Zhu, Shirley X.§; L?nning, Per E.**; B?rresen-Dale, Anne-Lise?; Brown, Patrick O.[curved stem paragraph sign ornament]??; Botstein, David* * Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA ? Department of Genetics, The Norwegian Radium Hospital, N-0310 Montebello Oslo, Norway § Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA [//] Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA [curved stem paragraph sign ornament] Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA # Department of Pathology, The Gade Institute, Haukeland University Hospital, N-5021 Bergen, Norway [white star] Department of Molecular Biology, University of Bergen, N-5020 Bergen, Norway ** Department of Oncology, Haukeland University Hospital, N-5021 Bergen, Norway ?? Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA ?These authors contributed equally to this work Received 7 February; accepted 25 May 2000. Correspondence and requests for materials should be addressed to D.B. (e-mail: botstein@) or P.O.B. (e-mail: pbrown@). Outline Abstract Methods Acknowledgements Graphics Figure 1 Figure 2 Figure 3 Abstract Human breast tumours are diverse in their natural history and in their responsiveness to treatments 1. Variation in transcriptional prog